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Peer-reviewedCC BY-NC 4.0Drug Design, Development and Therapy

Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review

  • Xiaolin Liao1
  • Hangxing Huang1
  • Junlong Cai1
  • Huaguan Lu2
  • Jing Li1,3
  • Hongfang Li4
  • Yueping Jiang1,3
4 affiliations
  1. 1Department of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China
  2. 2Institute of Grand Health, Guangxi Academy of Sciences, Nanning, Guangxi, People’s Republic of China
  3. 3Department of Pharmacy, Xiangya Hospital, Changsha, Hunan, People’s Republic of China
  4. 4Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China
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Abstract

Apigenin, a ubiquitous dietary flavone from vegetables, fruits and herbal teas, exhibits multi-target hypotensive effects, yet its poor water solubility limits oral bioavailability and industrial translation. Previous reviews only summarized its general bioactivities and anti-atherosclerotic effects, without comprehensively analyzing its antihypertensive mechanisms. Most evidence derives from preclinical studies; human trials merely use crude celery seed extracts instead of purified apigenin, lacking reliable clinical proof for its antihypertensive efficacy. This review summarizes apigenin’s sources, chemical properties, safety and solubility-enhanced delivery systems to support functional food exploitation. We elaborate four core antihypertensive pathways, and also point out translational bottlenecks and propose strategies including food-grade nanoformulation and standardized clinical trials. This work links preclinical mechanisms to food industry application, providing theoretical evidence for developing apigenin-enriched functional foods for hypertension adjuvant intervention.

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Cite

BibTeXRIS
BibTeX
@article{liao2026apigenin,
  title = {{Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review}},
  author = {Xiaolin Liao and Hangxing Huang and Junlong Cai and Huaguan Lu and Jing Li and Hongfang Li and Yueping Jiang},
  journal = {Drug Design, Development and Therapy},
  year = {2026},
  month = nov,
  doi = {10.2147/dddt.s629109},
  url = {https://doi.org/10.2147/dddt.s629109},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review
AU  - Xiaolin Liao
AU  - Hangxing Huang
AU  - Junlong Cai
AU  - Huaguan Lu
AU  - Jing Li
AU  - Hongfang Li
AU  - Yueping Jiang
PY  - 2026
DA  - 2026/11/01
JO  - Drug Design, Development and Therapy
DO  - 10.2147/dddt.s629109
UR  - https://doi.org/10.2147/dddt.s629109
AB  - Apigenin, a ubiquitous dietary flavone from vegetables, fruits and herbal teas, exhibits multi-target hypotensive effects, yet its poor water solubility limits oral bioavailability and industrial translation. Previous reviews only summarized its general bioactivities and anti-atherosclerotic effects, without comprehensively analyzing its antihypertensive mechanisms. Most evidence derives from preclinical studies; human trials merely use crude celery seed extracts instead of purified apigenin, lacking reliable clinical proof for its antihypertensive efficacy. This review summarizes apigenin’s sources, chemical properties, safety and solubility-enhanced delivery systems to support functional food exploitation. We elaborate four core antihypertensive pathways, and also point out translational bottlenecks and propose strategies including food-grade nanoformulation and standardized clinical trials. This work links preclinical mechanisms to food industry application, providing theoretical evidence for developing apigenin-enriched functional foods for hypertension adjuvant intervention.
SN  - 1177-8881
ER  -