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Peer-reviewedCC BY 4.0Frontiers in Oncology

Clinicopathological and molecular characteristics of second primary colorectal cancer in cancer survivors including MSI-H status and anatomical distribution

  • Yadong Liu1
  • Xuejuan Duan2
  • Shiwei Yang3
  • Yayu Zhang4
  • Shaohui Han5
5 affiliations
  1. 1Department of Oncology, Hebei General Hospital
  2. 2Department of Radiation Oncology, The Fourth Affiliated Hospital of Hebei Medical University
  3. 3Department of Gland Surgery, Hebei General Hospital
  4. 4Department of General Practice, Hebei General Hospital
  5. 5Department of Thoracic Surgery, Hebei General Hospital
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Abstract

Accurate data on microsatellite instability (MSI) in second primary colorectal cancer (CRC) are needed for precision oncology and guideline development. This study includes structured clinicopathological records from 77 cancer survivors diagnosed with second primary CRC. Variables encompass demographics, prior malignancy and treatment history, tumor location, histology, MSI status assessed via immunohistochemistry and polymerase chain reaction (PCR), and timing between malignancies. Data were systematically extracted following clear inclusion and exclusion criteria, with standardized definitions and quality checks. MSI status was determined using staining for four mismatch repair proteins, with PCR confirmation for equivocal results. The dataset’s structure ensures accessibility, interoperability, and reproducibility. It enables analyses of MSI prevalence, anatomical predictors, and clinical associations in second primary CRC, supporting secondary research on risk factors, biomarker correlates, and population-level outcomes.

FAIR ² CERTIFIED™ Explore interactive data here: 10.71728/senscience.qs2f-h81p

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Cite

BibTeXRIS
BibTeX
@article{liu2026clinicopathological,
  title = {{Clinicopathological and molecular characteristics of second primary colorectal cancer in cancer survivors including MSI-H status and anatomical distribution}},
  author = {Yadong Liu and Xuejuan Duan and Shiwei Yang and Yayu Zhang and Shaohui Han},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1952368},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1952368/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Clinicopathological and molecular characteristics of second primary colorectal cancer in cancer survivors including MSI-H status and anatomical distribution
AU  - Yadong Liu
AU  - Xuejuan Duan
AU  - Shiwei Yang
AU  - Yayu Zhang
AU  - Shaohui Han
PY  - 2026
DA  - 2026/10/23
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1952368
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1952368/full
AB  - Accurate data on microsatellite instability (MSI) in second primary colorectal cancer (CRC) are needed for precision oncology and guideline development. This study includes structured clinicopathological records from 77 cancer survivors diagnosed with second primary CRC. Variables encompass demographics, prior malignancy and treatment history, tumor location, histology, MSI status assessed via immunohistochemistry and polymerase chain reaction (PCR), and timing between malignancies. Data were systematically extracted following clear inclusion and exclusion criteria, with standardized definitions and quality checks. MSI status was determined using staining for four mismatch repair proteins, with PCR confirmation for equivocal results. The dataset’s structure ensures accessibility, interoperability, and reproducibility. It enables analyses of MSI prevalence, anatomical predictors, and clinical associations in second primary CRC, supporting secondary research on risk factors, biomarker correlates, and population-level outcomes.  FAIR ² CERTIFIED™ Explore interactive data here: 10.71728/senscience.qs2f-h81p
SN  - 2234-943X
ER  -