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Peer-reviewedCC BY-NC-NDActa pharmaceutica Sinica. B

Pharmacological agents for promoting diabetic wound healing

  • Jiamin Shang1
  • Zhaoyu Liu1
  • Meidai Liang2
  • Xiaomeng Ye1
  • Zijie Yin1
  • Zeyu Yang1
  • Jiaqi Zhao1
  • Hongjing Wu1
  • Guanhua Du1
  • Xiuying Yang1
  1. 1Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica of Peking Union Medical College, Beijing 100050, China
  2. 2Department of Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
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Abstract

Diabetic wounds are highly susceptible to chronicity and infection due to impaired healing involving multiple pathophysiological factors. Despite extensive preclinical and clinical research, few approved drugs have been shown to effectively accelerate diabetic wound healing. This review highlights pharmacological interventions for diabetic wound healing, summarizes the current status of drug development, and discusses their potential mechanisms of action. These agents include inflammation-modulating agents, pro-proliferative agents, remodeling-regulating agents, hypoxia- and microcirculation-targeting agents, antioxidant agents, and multi-target agents, such as bioactive constituents from plants and traditional Chinese medicine (TCM) formulas. This review aims to guide future drug development strategies for diabetic wound healing.

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Cite

BibTeXRIS
BibTeX
@article{shang2026pharmacological,
  title = {{Pharmacological agents for promoting diabetic wound healing}},
  author = {Jiamin Shang and Zhaoyu Liu and Meidai Liang and Xiaomeng Ye and Zijie Yin and Zeyu Yang and Jiaqi Zhao and Hongjing Wu and Guanhua Du and Xiuying Yang},
  journal = {Acta pharmaceutica Sinica. B},
  year = {2026},
  month = sep,
  doi = {10.1016/j.apsb.2026.09.007},
  url = {https://europepmc.org/article/PMC/PMC13729541},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Pharmacological agents for promoting diabetic wound healing
AU  - Jiamin Shang
AU  - Zhaoyu Liu
AU  - Meidai Liang
AU  - Xiaomeng Ye
AU  - Zijie Yin
AU  - Zeyu Yang
AU  - Jiaqi Zhao
AU  - Hongjing Wu
AU  - Guanhua Du
AU  - Xiuying Yang
PY  - 2026
DA  - 2026/09/12
JO  - Acta pharmaceutica Sinica. B
DO  - 10.1016/j.apsb.2026.09.007
UR  - https://europepmc.org/article/PMC/PMC13729541
AB  - Diabetic wounds are highly susceptible to chronicity and infection due to impaired healing involving multiple pathophysiological factors. Despite extensive preclinical and clinical research, few approved drugs have been shown to effectively accelerate diabetic wound healing. This review highlights pharmacological interventions for diabetic wound healing, summarizes the current status of drug development, and discusses their potential mechanisms of action. These agents include inflammation-modulating agents, pro-proliferative agents, remodeling-regulating agents, hypoxia- and microcirculation-targeting agents, antioxidant agents, and multi-target agents, such as bioactive constituents from plants and traditional Chinese medicine (TCM) formulas. This review aims to guide future drug development strategies for diabetic wound healing.
SN  - 2211-3835
SN  - 2211-3843
ER  -