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Peer-reviewedCC BYMaterials Today Bio

Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing

  • Xuemei Yuan1
  • Haiting Zou1
  • Jiaye Li1
  • Jingyi Chen1
  • Fengyuan Wang2
  • Jue Zhang2
  • Qianting Zhang2
  • Ming Chen2
  • Yue Lin3
  • Dongfeng Zheng3
  • Guopu Chen4
4 affiliations
  1. 1Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, China
  2. 2Department of Burns and Plastic Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210096, China
  3. 3Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, China; Corresponding author.
  4. 4Department of Burns and Plastic Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210096, China; Corresponding author.
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Abstract

Adipose-derived stem cells (ADSCs) hold substantial therapeutic potential for diabetic foot ulcers (DFUs). However, their efficacy is often limited by poor survival within the harsh microenvironment of chronic wounds. In this study, we developed a multifunctional bio-derived hydrogel composed of gelatin methacrylate (GelMA), glycyrrhizic acid (GA), and ferrous ions (Fe 2+ ) that integrates ADSCs with local microenvironment modulation. This approach targets key pathological challenges in DFUs treatment, including persistent inflammation, impaired angiogenesis, and oxidative stress. The hydrogel demonstrated potent antibacterial, antioxidant, and pro-angiogenic activities. Moreover, it significantly accelerated diabetic wound healing, enhanced re-epithelialization and collagen deposition, and promoted macrophage polarization toward the reparative M2 phenotype, thereby effectively improving the wound microenvironment. These results indicate that the GelMA/GA/Fe@ADSCs hydrogel is a promising regenerative therapy with strong translational potential for DFUs and other chronic wounds.

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Cite

BibTeXRIS
BibTeX
@article{yuan2026multifunctional,
  title = {{Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing}},
  author = {Xuemei Yuan and Haiting Zou and Jiaye Li and Jingyi Chen and Fengyuan Wang and Jue Zhang and Qianting Zhang and Ming Chen and Yue Lin and Dongfeng Zheng and Guopu Chen},
  journal = {Materials Today Bio},
  year = {2026},
  month = nov,
  doi = {10.1016/j.mtbio.2026.103803},
  url = {https://doi.org/10.1016/j.mtbio.2026.103803},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing
AU  - Xuemei Yuan
AU  - Haiting Zou
AU  - Jiaye Li
AU  - Jingyi Chen
AU  - Fengyuan Wang
AU  - Jue Zhang
AU  - Qianting Zhang
AU  - Ming Chen
AU  - Yue Lin
AU  - Dongfeng Zheng
AU  - Guopu Chen
PY  - 2026
DA  - 2026/11/09
JO  - Materials Today Bio
DO  - 10.1016/j.mtbio.2026.103803
UR  - https://doi.org/10.1016/j.mtbio.2026.103803
AB  - Adipose-derived stem cells (ADSCs) hold substantial therapeutic potential for diabetic foot ulcers (DFUs). However, their efficacy is often limited by poor survival within the harsh microenvironment of chronic wounds. In this study, we developed a multifunctional bio-derived hydrogel composed of gelatin methacrylate (GelMA), glycyrrhizic acid (GA), and ferrous ions (Fe 2+ ) that integrates ADSCs with local microenvironment modulation. This approach targets key pathological challenges in DFUs treatment, including persistent inflammation, impaired angiogenesis, and oxidative stress. The hydrogel demonstrated potent antibacterial, antioxidant, and pro-angiogenic activities. Moreover, it significantly accelerated diabetic wound healing, enhanced re-epithelialization and collagen deposition, and promoted macrophage polarization toward the reparative M2 phenotype, thereby effectively improving the wound microenvironment. These results indicate that the GelMA/GA/Fe@ADSCs hydrogel is a promising regenerative therapy with strong translational potential for DFUs and other chronic wounds.
SN  - 2590-0064
ER  -