Headache impact and quality of life following endometriosis surgery in women: a single-center observational study.
4 affiliations
- 1Department of Obstetrics and Gynecology Nursing, Faculty of Nursing, Mersin University, Mersin, Türkiye. [email protected].
- 2Department of Obstetrics and Gynecology, Tarsus State Hospital, Mersin, Türkiye.
- 3Department of Obstetrics and Gynecology, Faculty of Medicine, Mersin University, Mersin, Türkiye.
- 4Department of Biostatistics, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Türkiye.
Abstract
Background
Endometriosis and migraine are common chronic conditions in women of reproductive age that impair quality of life and frequently co-occur as comorbid conditions. Evidence regarding the effects of treatments targeting one of these conditions on the course of the other remains limited. In particular, the association between endometriosis surgery and headache burden and quality of life has not been sufficiently investigated. The aim of this study was to examine changes in headache burden and quality of life following endometriosis surgery in women with and without migraine.Methods
This single-center observational study included 88 women who had undergone endometriosis surgery between 3 months and 5 years prior to enrollment. Participants completed the Headache Impact Test-6 and the 12-Item Short Form Health Survey by retrospectively recalling their preoperative status, as prospective preoperative questionnaire records were not available, and reporting their current postoperative status. Changes over time, group differences, and time-by-group interactions were analyzed using mixed-design analysis of variance. Additional sensitivity analyses stratified by follow-up duration were performed to explore the potential influence of postoperative interval on change scores.Results
In both women with and without migraine, headache burden scores were lower and physical and mental quality of life component scores were higher at the postoperative assessment than in the retrospectively recalled preoperative period (p < 0.001). These differences were more pronounced among women with migraine.Conclusion
Women reported lower headache burden and better quality of life at the postoperative assessment than in the retrospectively recalled preoperative period in both groups, with greater changes observed among women with migraine. Given the retrospective assessment of preoperative status, prospective studies are needed to confirm these findings, optimize multidisciplinary management of endometriosis and migraine and to identify patient subgroups most likely to benefit from surgical intervention.
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BibTeX
@article{degirmenci2026headache,
title = {{Headache impact and quality of life following endometriosis surgery in women: a single-center observational study.}},
author = {Filiz Değirmenci and Hamza Yildiz and Hakan Aytan and Mustafa Agah Teki̇ndal},
journal = {BMC women's health},
year = {2026},
month = jul,
doi = {10.1186/s12905-026-04720-8},
url = {https://europepmc.org/article/MED/42907837},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Headache impact and quality of life following endometriosis surgery in women: a single-center observational study.
AU - Filiz Değirmenci
AU - Hamza Yildiz
AU - Hakan Aytan
AU - Mustafa Agah Teki̇ndal
PY - 2026
DA - 2026/07/01
JO - BMC women's health
DO - 10.1186/s12905-026-04720-8
UR - https://europepmc.org/article/MED/42907837
AB - Background Endometriosis and migraine are common chronic conditions in women of reproductive age that impair quality of life and frequently co-occur as comorbid conditions. Evidence regarding the effects of treatments targeting one of these conditions on the course of the other remains limited. In particular, the association between endometriosis surgery and headache burden and quality of life has not been sufficiently investigated. The aim of this study was to examine changes in headache burden and quality of life following endometriosis surgery in women with and without migraine.Methods This single-center observational study included 88 women who had undergone endometriosis surgery between 3 months and 5 years prior to enrollment. Participants completed the Headache Impact Test-6 and the 12-Item Short Form Health Survey by retrospectively recalling their preoperative status, as prospective preoperative questionnaire records were not available, and reporting their current postoperative status. Changes over time, group differences, and time-by-group interactions were analyzed using mixed-design analysis of variance. Additional sensitivity analyses stratified by follow-up duration were performed to explore the potential influence of postoperative interval on change scores.Results In both women with and without migraine, headache burden scores were lower and physical and mental quality of life component scores were higher at the postoperative assessment than in the retrospectively recalled preoperative period (p < 0.001). These differences were more pronounced among women with migraine.Conclusion Women reported lower headache burden and better quality of life at the postoperative assessment than in the retrospectively recalled preoperative period in both groups, with greater changes observed among women with migraine. Given the retrospective assessment of preoperative status, prospective studies are needed to confirm these findings, optimize multidisciplinary management of endometriosis and migraine and to identify patient subgroups most likely to benefit from surgical intervention.
SN - 1472-6874
ER -