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Peer-reviewedCC BY-NC-NDAnnals of medicine and surgery (2012)

Trends in malignant melanoma mortality in the United States, 1999–2024: a population-based retrospective epidemiologic analysis

  • Ibraheem Altamimi1
  • Maha Mohammed Alkharisi2
  • Naif Mohammed Alzahrani3
  • Nimerta Lohana4
  • Abeer Abdulkarim Aloraini5
  • Abdelmalek Ammar AlHaj Abdelghani6
  • Hoor Jawad Alalwan7
  • Lojain Abdulsalam Alkhaldi8
  • Abdulrhman Abdulaziz Alnoshan9
  • Abdullah Almeziny10
  • Hind Hussain Alghtani11
  • Lubna Musa Altamimi9
2 more authors
  • Haifa Alfalah1
  • Aalaa Saleh12
12 affiliations
  1. 1King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia
  2. 2College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
  3. 3College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  4. 4Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  5. 5College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
  6. 6College of Medicine, Qassim University, Unaizah, Qassim, Saudi Arabia
  7. 7College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  8. 8College of Medicine, Jouf University, Al Jouf, Saudi Arabia
  9. 9College of Medicine, King Saud University, Riyadh, Saudi Arabia
  10. 10Department of Dermatology, King Faisal Specialist Hospital & Research Centre (KFSHRC), Riyadh, Saudi Arabia
  11. 11College of Medicine, Najran University, Najran, Saudi Arabia
  12. 12Department of Internal Medicine, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
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Abstract

Introduction

Malignant melanoma (MM) is among the most lethal skin cancers, with rising global incidence and persistent mortality disparities. In the United States, long-term trends in MM-related mortality and their variation across demographic and geographic subgroups remain incompletely defined.Methods

We conducted a population-based analysis of MM mortality in the United States from 1999 to 2024, using national mortality data. Age-adjusted mortality rates per 100 000 population were calculated and stratified by sex, age, race/ethnicity, geographic region, and urbanization level. Temporal trends were evaluated using annual percent changes.Results

Between 1999 and 2024, MM mortality demonstrated dynamic shifts, with an initial increase followed by a decline and stabilization after 2017. Men consistently exhibited higher mortality rates than women, and older adults experienced disproportionately greater burdens. Racial and ethnic minorities, despite a lower incidence, showed poorer survival. Geographic variation was evident, with elevated mortality in certain states and in non-metropolitan areas relative to metropolitan regions. The decline in mortality corresponded temporally with the introduction of immune checkpoint inhibitors and targeted therapies, although disparities persisted across subgroups.Conclusion

MM mortality in the United States has improved over the past two decades, largely due to advances in treatment. However, enduring disparities by sex, age, race and ethnicity, and geography emphasize the need for equitable access to therapies, improved early detection, and targeted public health interventions to sustain progress and reduce inequities.

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Cite

BibTeXRIS
BibTeX
@article{altamimi2026trends,
  title = {{Trends in malignant melanoma mortality in the United States, 1999–2024: a population-based retrospective epidemiologic analysis}},
  author = {Ibraheem Altamimi and Maha Mohammed Alkharisi and Naif Mohammed Alzahrani and Nimerta Lohana and Abeer Abdulkarim Aloraini and Abdelmalek Ammar AlHaj Abdelghani and Hoor Jawad Alalwan and Lojain Abdulsalam Alkhaldi and Abdulrhman Abdulaziz Alnoshan and Abdullah Almeziny and Hind Hussain Alghtani and Lubna Musa Altamimi and Haifa Alfalah and Aalaa Saleh},
  journal = {Annals of medicine and surgery (2012)},
  year = {2026},
  month = oct,
  doi = {10.1097/ms9.0000000000005737},
  url = {https://europepmc.org/article/PMC/PMC13754381},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Trends in malignant melanoma mortality in the United States, 1999–2024: a population-based retrospective epidemiologic analysis
AU  - Ibraheem Altamimi
AU  - Maha Mohammed Alkharisi
AU  - Naif Mohammed Alzahrani
AU  - Nimerta Lohana
AU  - Abeer Abdulkarim Aloraini
AU  - Abdelmalek Ammar AlHaj Abdelghani
AU  - Hoor Jawad Alalwan
AU  - Lojain Abdulsalam Alkhaldi
AU  - Abdulrhman Abdulaziz Alnoshan
AU  - Abdullah Almeziny
AU  - Hind Hussain Alghtani
AU  - Lubna Musa Altamimi
AU  - Haifa Alfalah
AU  - Aalaa Saleh
PY  - 2026
DA  - 2026/10/27
JO  - Annals of medicine and surgery (2012)
DO  - 10.1097/ms9.0000000000005737
UR  - https://europepmc.org/article/PMC/PMC13754381
AB  - Introduction  Malignant melanoma (MM) is among the most lethal skin cancers, with rising global incidence and persistent mortality disparities. In the United States, long-term trends in MM-related mortality and their variation across demographic and geographic subgroups remain incompletely defined.Methods  We conducted a population-based analysis of MM mortality in the United States from 1999 to 2024, using national mortality data. Age-adjusted mortality rates per 100 000 population were calculated and stratified by sex, age, race/ethnicity, geographic region, and urbanization level. Temporal trends were evaluated using annual percent changes.Results  Between 1999 and 2024, MM mortality demonstrated dynamic shifts, with an initial increase followed by a decline and stabilization after 2017. Men consistently exhibited higher mortality rates than women, and older adults experienced disproportionately greater burdens. Racial and ethnic minorities, despite a lower incidence, showed poorer survival. Geographic variation was evident, with elevated mortality in certain states and in non-metropolitan areas relative to metropolitan regions. The decline in mortality corresponded temporally with the introduction of immune checkpoint inhibitors and targeted therapies, although disparities persisted across subgroups.Conclusion  MM mortality in the United States has improved over the past two decades, largely due to advances in treatment. However, enduring disparities by sex, age, race and ethnicity, and geography emphasize the need for equitable access to therapies, improved early detection, and targeted public health interventions to sustain progress and reduce inequities.
SN  - 2049-0801
ER  -