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Peer-reviewedCC BY-NCRSC advances

Bimetallic ZIF nanoplatform for pH-responsive curcumin delivery: synthesis, characterization, and in vitro evaluation.

  • Luan Minh Nguyen1,2
  • Giao Thuy Quynh Vu1
  • Tan Phat Nguyen1
  • Manh Hoang Tran1
  • Thi My Huyen Nguyen1
  • Long Binh Vong3,4
  • Dai Hai Nguyen1,2
4 affiliations
  1. 1Institute of Advanced Technology, Vietnam Academy of Science and Technology 1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam [email protected] [email protected].
  2. 2Graduate University of Science and Technology, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Street, Nghia Do Ward Hanoi City 100000 Vietnam.
  3. 3School of Biomedical Engineering, International University Ho Chi Minh City 700000 Vietnam.
  4. 4Vietnam National University Ho Chi Minh City Ho Chi Minh City 700000 Vietnam.
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Abstract

The exploration of zeolitic imidazolate framework (ZIF)-based nanoplatforms for drug delivery has attracted increasing attention in recent years. In this study, a bimetallic ZIF (BZIF) containing Zn and Co was synthesized through a simple one-pot approach under mild conditions. The formation of BZIF was confirmed through comprehensive physicochemical characterization. Curcumin (CUR) was subsequently loaded onto BZIF to obtain the CBZIF nanoplatform. CBZIF exhibited pH-responsive CUR release, with cumulative release reaching 78.19% at pH 5.5 compared with 44.25% at pH 7.4 after 72 h. In vitro studies demonstrated that CBZIF maintained favorable biocompatibility toward normal L929 cells while exhibiting enhanced anticancer activity against C26 cancer cells compared with free CUR and pristine BZIF. Overall, these findings suggest that CBZIF is a promising nanoplatform for pH-responsive CUR delivery and provide a basis for further investigation of its potential biomedical applications.

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Cite

BibTeXRIS
BibTeX
@article{nguyen2026bimetallic,
  title = {{Bimetallic ZIF nanoplatform for pH-responsive curcumin delivery: synthesis, characterization, and in vitro evaluation.}},
  author = {Luan Minh Nguyen and Giao Thuy Quynh Vu and Tan Phat Nguyen and Manh Hoang Tran and Thi My Huyen Nguyen and Long Binh Vong and Dai Hai Nguyen},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra08606c},
  url = {https://europepmc.org/article/MED/42898706},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Bimetallic ZIF nanoplatform for pH-responsive curcumin delivery: synthesis, characterization, and in vitro evaluation.
AU  - Luan Minh Nguyen
AU  - Giao Thuy Quynh Vu
AU  - Tan Phat Nguyen
AU  - Manh Hoang Tran
AU  - Thi My Huyen Nguyen
AU  - Long Binh Vong
AU  - Dai Hai Nguyen
PY  - 2026
DA  - 2026/10/01
JO  - RSC advances
DO  - 10.1039/d6ra08606c
UR  - https://europepmc.org/article/MED/42898706
AB  - The exploration of zeolitic imidazolate framework (ZIF)-based nanoplatforms for drug delivery has attracted increasing attention in recent years. In this study, a bimetallic ZIF (BZIF) containing Zn and Co was synthesized through a simple one-pot approach under mild conditions. The formation of BZIF was confirmed through comprehensive physicochemical characterization. Curcumin (CUR) was subsequently loaded onto BZIF to obtain the CBZIF nanoplatform. CBZIF exhibited pH-responsive CUR release, with cumulative release reaching 78.19% at pH 5.5 compared with 44.25% at pH 7.4 after 72 h. In vitro studies demonstrated that CBZIF maintained favorable biocompatibility toward normal L929 cells while exhibiting enhanced anticancer activity against C26 cancer cells compared with free CUR and pristine BZIF. Overall, these findings suggest that CBZIF is a promising nanoplatform for pH-responsive CUR delivery and provide a basis for further investigation of its potential biomedical applications.
SN  - 2046-2069
ER  -