Evaluation of Tagetes erecta-incorporated Ag–Co bimetallic nano particles: characterization and enhancement of their antibacterial, antioxidant, and cytotoxic activities using an in vitro approach
- 1Department of Chemistry, College of Engineering and Technology, SRM Institute of Science and Technology Kattankulathur-603 203 Tamil Nadu India
- 2Department of Chemical Engineering, College of Engineering and Technology, SRM Institute of Science and Technology Kattankulathur-603 203 Tamil Nadu India
Abstract
In this study, we synthesized, characterized, and biologically evaluated Ag–Co BNPs (bimetallic nanoparticles) using Tagetes erecta aqueous extract to examine their antibacterial, antioxidant, and cytotoxic properties. The Tagetes erecta extract was found to be biologically active by phytochemical screening. The synthesized Ag–Co BNPs nanoparticle was characterized by UV-visible, FTIR, P-XRD, HRSEM, TEM, and XPS. At about 430 nm, the UV examination revealed the characteristic absorption band. FTIR confirmed that functional group analysis was present. XRD examination yielded an average crystalline size of 3.5 nm for Ag–Co BNPs. SEM and TEM pictures revealed a spherical shape for the biosynthesised Ag–Co BNPs. Ag, Co, C, and O display different peaks in the XPS survey spectra of Ag–Co BNPs. According to the antibacterial study, Staphylococcus aureus (16 mm) showed increased activity when compared with the other three negative gram bacteria; the zone of inhibition grew as the Ag–Co BNPs concentration increased. Additionally, the BNPs showed greater antioxidant capacity, with an IC50 value of 202.5 µg mL−1 for scavenging DPPH free radicals. HepG2 cell line cytotoxicity tests showed an IC50 of 52.39 µg mL−1, which also compared with the H6C7 human normal pancreatic cell line. These results indicate the potential use of ecologically friendly Ag–Co BNPs in future drug delivery systems.
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BibTeX
@article{chidhambaram2026evaluation,
title = {{Evaluation of Tagetes erecta-incorporated Ag–Co bimetallic nano particles: characterization and enhancement of their antibacterial, antioxidant, and cytotoxic activities using an in vitro approach}},
author = {Eswari Chidhambaram and Sofiya Karunanithi},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07408a},
url = {https://europepmc.org/article/PMC/PMC13721916},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Evaluation of Tagetes erecta-incorporated Ag–Co bimetallic nano particles: characterization and enhancement of their antibacterial, antioxidant, and cytotoxic activities using an in vitro approach
AU - Eswari Chidhambaram
AU - Sofiya Karunanithi
PY - 2026
DA - 2026/10/30
JO - RSC advances
DO - 10.1039/d6ra07408a
UR - https://europepmc.org/article/PMC/PMC13721916
AB - In this study, we synthesized, characterized, and biologically evaluated Ag–Co BNPs (bimetallic nanoparticles) using Tagetes erecta aqueous extract to examine their antibacterial, antioxidant, and cytotoxic properties. The Tagetes erecta extract was found to be biologically active by phytochemical screening. The synthesized Ag–Co BNPs nanoparticle was characterized by UV-visible, FTIR, P-XRD, HRSEM, TEM, and XPS. At about 430 nm, the UV examination revealed the characteristic absorption band. FTIR confirmed that functional group analysis was present. XRD examination yielded an average crystalline size of 3.5 nm for Ag–Co BNPs. SEM and TEM pictures revealed a spherical shape for the biosynthesised Ag–Co BNPs. Ag, Co, C, and O display different peaks in the XPS survey spectra of Ag–Co BNPs. According to the antibacterial study, Staphylococcus aureus (16 mm) showed increased activity when compared with the other three negative gram bacteria; the zone of inhibition grew as the Ag–Co BNPs concentration increased. Additionally, the BNPs showed greater antioxidant capacity, with an IC50 value of 202.5 µg mL−1 for scavenging DPPH free radicals. HepG2 cell line cytotoxicity tests showed an IC50 of 52.39 µg mL−1, which also compared with the H6C7 human normal pancreatic cell line. These results indicate the potential use of ecologically friendly Ag–Co BNPs in future drug delivery systems.
SN - 2046-2069
ER -