Emerging roles of nanocomposites for management of skin cancers: from tumor eradication to post-surgical treatment
7 affiliations
- 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- 2Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- 3Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- 4School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
- 5School of Engineering, Macquarie University, Sydney, Australia
- 6Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- 7Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Abstract
Skin cancers, including melanoma and non-melanoma subtypes, remain a significant global health challenge since current treatment approaches including surgery, radiotherapy, and chemotherapy, all cause systemic toxicity and lack specificity. In this context, the combination of tissue engineering and nanotechnology has emerged as a versatile solution, offering targeted drug delivery, enhanced therapeutic efficacy, and reduced side effects. This review explores the latest advancements in nanomedicine for post-surgery skin cancer wound healing, focusing on various nanocarriers, including metallic nanoparticles (NPs) (e.g., gold, silver), polymeric NPs (e.g., chitosan), and bioactive glasses. These nanoplatforms enhance drug bioavailability, facilitate controlled release, and enable precise tumor targeting while minimizing damage to healthy tissues. Additionally, the review highlights the importance of encapsulating NPs within various nanocomposites (such as injectable hydrogels and electrospun nanofibers) in tumor eradication and skin regeneration, underlining their potential in photothermal therapy, photo/chemodynamic therapy, and wound healing. Despite promising results, challenges such as scalability, long-term safety, and personalized treatment strategies still remain. Future research should focus on optimizing NP design, integrating multifunctional systems, and advancing clinical applications to reationize skin cancer therapy and improve patient outcomes.
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BibTeX
@article{simin2026emerging,
title = {{Emerging roles of nanocomposites for management of skin cancers: from tumor eradication to post-surgical treatment}},
author = {Nazarnezhad Simin and Sadeghpour Sajjad and Habibi Amin and Seyedasli Naisana and Aghajanloo Behrouz and Darbandi Zahra Jalayeri and Yaghoubi Fatemeh and Khazaei Majid},
journal = {Nanotechnology Reviews},
year = {2026},
month = oct,
doi = {10.1515/ntrev-2025-0381},
url = {https://doi.org/10.1515/ntrev-2025-0381},
note = {CC BY},
}
RIS
TY - JOUR
TI - Emerging roles of nanocomposites for management of skin cancers: from tumor eradication to post-surgical treatment
AU - Nazarnezhad Simin
AU - Sadeghpour Sajjad
AU - Habibi Amin
AU - Seyedasli Naisana
AU - Aghajanloo Behrouz
AU - Darbandi Zahra Jalayeri
AU - Yaghoubi Fatemeh
AU - Khazaei Majid
PY - 2026
DA - 2026/10/26
JO - Nanotechnology Reviews
DO - 10.1515/ntrev-2025-0381
UR - https://doi.org/10.1515/ntrev-2025-0381
AB - Skin cancers, including melanoma and non-melanoma subtypes, remain a significant global health challenge since current treatment approaches including surgery, radiotherapy, and chemotherapy, all cause systemic toxicity and lack specificity. In this context, the combination of tissue engineering and nanotechnology has emerged as a versatile solution, offering targeted drug delivery, enhanced therapeutic efficacy, and reduced side effects. This review explores the latest advancements in nanomedicine for post-surgery skin cancer wound healing, focusing on various nanocarriers, including metallic nanoparticles (NPs) (e.g., gold, silver), polymeric NPs (e.g., chitosan), and bioactive glasses. These nanoplatforms enhance drug bioavailability, facilitate controlled release, and enable precise tumor targeting while minimizing damage to healthy tissues. Additionally, the review highlights the importance of encapsulating NPs within various nanocomposites (such as injectable hydrogels and electrospun nanofibers) in tumor eradication and skin regeneration, underlining their potential in photothermal therapy, photo/chemodynamic therapy, and wound healing. Despite promising results, challenges such as scalability, long-term safety, and personalized treatment strategies still remain. Future research should focus on optimizing NP design, integrating multifunctional systems, and advancing clinical applications to reationize skin cancer therapy and improve patient outcomes.
SN - 2191-9097
SN - 2191-9089
ER -