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PreprintCC BYChemRxiv

Covalently Functionalized Two-Dimensional Red Phosphorus Nanosheets: Efficient Platform for Broad-Spectrum Biofilm Eradication

  • AadithyaKannan Ravi1
  • Mahesh M. Lalitha1
  • Debopam Ghosh1
  • Ajay Kumar2,3
  • Navya G. Praveen1
  • Athira V Pramodh2,3
  • Easa Nagamalleswari2,3
  • Rajendra Kurapati1
  • Dr. Rajendra Kurapati
  1. 1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Maruthamala P.O. Vithura, Kerala, India, 695551
  2. 2Microbial Type Culture Collection and Gene Bank
  3. 3CSIR- Institute of Microbial Technology
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Abstract

Red phosphorus (RP) has gained considerable attention owing to its high chemical stability and narrow band gap, making it a promising material for applications in photocatalysis, energy storage, and related areas. Covalent functionalization has emerged as an effective approach to enhance the surface reactivity, dispersibility, and chemical stability of nanomaterials. Herein, we report covalently modified RP nanosheets prepared using aryl diazonium molecules as organic ligands. The functionalized RP nanosheets (f-RPNS) exhibit better colloidal stability and dispersibility compared to pristine RP nanosheets. The in vitro antibiofilm studies of f-RPNS, with and without NIR irradiation, demonstrated that the covalently modified RPNS can eradicate drug-resistant bacterial biofilms even in the absence of photothermal treatment. We highlight the potential of f-RPNS across various biomedical fields, particularly in biofilm eradication.

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Cite

BibTeXRIS
BibTeX
@misc{ravi2026covalently,
  title = {{Covalently Functionalized Two-Dimensional Red Phosphorus Nanosheets: Efficient Platform for Broad-Spectrum Biofilm Eradication}},
  author = {AadithyaKannan Ravi and Mahesh M. Lalitha and Debopam Ghosh and Ajay Kumar and Navya G. Praveen and Athira V Pramodh and Easa Nagamalleswari and Rajendra Kurapati and Dr. Rajendra Kurapati},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15008947/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008947/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Covalently Functionalized Two-Dimensional Red Phosphorus Nanosheets: Efficient Platform for Broad-Spectrum Biofilm Eradication
AU  - AadithyaKannan Ravi
AU  - Mahesh M. Lalitha
AU  - Debopam Ghosh
AU  - Ajay Kumar
AU  - Navya G. Praveen
AU  - Athira V Pramodh
AU  - Easa Nagamalleswari
AU  - Rajendra Kurapati
AU  - Dr. Rajendra Kurapati
PY  - 2026
DA  - 2026/09/16
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15008947/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008947/v1
AB  - Red phosphorus (RP) has gained considerable attention owing to its high chemical stability and narrow band gap, making it a promising material for applications in photocatalysis, energy storage, and related areas. Covalent functionalization has emerged as an effective approach to enhance the surface reactivity, dispersibility, and chemical stability of nanomaterials. Herein, we report covalently modified RP nanosheets prepared using aryl diazonium molecules as organic ligands. The functionalized RP nanosheets (f-RPNS) exhibit better colloidal stability and dispersibility compared to pristine RP nanosheets. The in vitro antibiofilm studies of f-RPNS, with and without NIR irradiation, demonstrated that the covalently modified RPNS can eradicate drug-resistant bacterial biofilms even in the absence of photothermal treatment. We highlight the potential of f-RPNS across various biomedical fields, particularly in biofilm eradication.
ER  -