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Peer-reviewedCC BY-NCFuture science OA

Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.

  • Kanokwan Nahok1,2
  • Chalongchai Chalermwat2,3
  • Ubon Cha'on2,3
  • Apinya Jusakul2,4
  • Patcharee Boonsiri3
  • Angkor Chamdam3
  • Ratthaphol Kraiklang2,5
  • Patcharaporn Tippayawat2,6
  • Sirirat Anutrakulchai2,7
  • Worachart Lert-Itthiporn2,3
7 affiliations
  1. 1Research and Innovation Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  2. 2Chronic Kidney Disease Prevention in the Northeast of Thailand (CKDNET), Khon Kaen University, Khon Kaen, Thailand.
  3. 3Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  4. 4The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
  5. 5Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
  6. 6Department of Medical Technology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
  7. 7Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
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Abstract

Background

Patients with chronic kidney disease (CKD) may be vulnerable to thiamine insufficiency due to dietary restrictions, altered metabolism, and renal replacement therapy. We aimed to determine the prevalence of functional thiamine deficiency, its distribution across CKD stages, and the associated clinical factors in a Thai population.Areas covered

Thiamine status was assessed in red blood cells using the erythrocyte transketolase activity coefficient (ETKAC) assay. Participants (n = 605) were categorized as having normal thiamine status (ETKAC ≤1.25) or functional thiamine deficiency (ETKAC >1.25). The prevalence of functional thiamine deficiency was 6.1% overall and 6.4% among participants with CKD. Univariate analyses of participants with CKD showed that higher systolic blood pressure (SBP), hypertension, and lower estimated glomerular filtration rate (eGFR) were associated with functional thiamine deficiency. In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002).Expert opinion/commentary

Functional thiamine deficiency was observed in a subset of participants, particularly in patients with CKD and hypertension, supporting further investigation of thiamine status in CKD populations.

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Cite

BibTeXRIS
BibTeX
@article{nahok2026functional,
  title = {{Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.}},
  author = {Kanokwan Nahok and Chalongchai Chalermwat and Ubon Cha'on and Apinya Jusakul and Patcharee Boonsiri and Angkor Chamdam and Ratthaphol Kraiklang and Patcharaporn Tippayawat and Sirirat Anutrakulchai and Worachart Lert-Itthiporn},
  journal = {Future science OA},
  year = {2026},
  month = oct,
  doi = {10.1080/20565623.2026.2738750},
  url = {https://europepmc.org/article/MED/42852733},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.
AU  - Kanokwan Nahok
AU  - Chalongchai Chalermwat
AU  - Ubon Cha'on
AU  - Apinya Jusakul
AU  - Patcharee Boonsiri
AU  - Angkor Chamdam
AU  - Ratthaphol Kraiklang
AU  - Patcharaporn Tippayawat
AU  - Sirirat Anutrakulchai
AU  - Worachart Lert-Itthiporn
PY  - 2026
DA  - 2026/10/09
JO  - Future science OA
DO  - 10.1080/20565623.2026.2738750
UR  - https://europepmc.org/article/MED/42852733
AB  - Background  Patients with chronic kidney disease (CKD) may be vulnerable to thiamine insufficiency due to dietary restrictions, altered metabolism, and renal replacement therapy. We aimed to determine the prevalence of functional thiamine deficiency, its distribution across CKD stages, and the associated clinical factors in a Thai population.Areas covered  Thiamine status was assessed in red blood cells using the erythrocyte transketolase activity coefficient (ETKAC) assay. Participants (n = 605) were categorized as having normal thiamine status (ETKAC ≤1.25) or functional thiamine deficiency (ETKAC >1.25). The prevalence of functional thiamine deficiency was 6.1% overall and 6.4% among participants with CKD. Univariate analyses of participants with CKD showed that higher systolic blood pressure (SBP), hypertension, and lower estimated glomerular filtration rate (eGFR) were associated with functional thiamine deficiency. In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002).Expert opinion/commentary  Functional thiamine deficiency was observed in a subset of participants, particularly in patients with CKD and hypertension, supporting further investigation of thiamine status in CKD populations.
SN  - 2056-5623
ER  -