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Peer-reviewedCC BY-NC-NDInternal Medicine

A Temporal Pole Lesion in Neuronal Intranuclear Inclusion Disease: A Case Report

Abstract

An 81-year-old woman was transferred to our hospital due to a consciousness disorder. MRI of her cranium revealed white matter lesions and lesions in the cerebellar paravermis, splenium of the corpus callosum, and a left temporal pole on fluid-attenuated inversion recovery (FLAIR) sequences. Diffusion-weighted imaging (DWI) revealed hyperintensity at the left frontal corticomedullary junction of the brain. She was diagnosed with neuronal intranuclear inclusion disease (NIID) via a skin biopsy and genetic analysis. These lesions were evident before the DWI hyperintensity was clear. When a lesion in the temporal pole is observed, then NIID should be considered in the differential diagnosis.

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BibTeX
@article{inaba2026temporal,
  title = {{A Temporal Pole Lesion in Neuronal Intranuclear Inclusion Disease: A Case Report}},
  author = {Tomoya Inaba and Yoshinori Hirata and Hidehiro Ishikawa and Asako Tamura and Jun Sone and Akihiro Shindo},
  journal = {Internal Medicine},
  year = {2026},
  month = jul,
  doi = {10.2169/internalmedicine.7301-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7301-26/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - A Temporal Pole Lesion in Neuronal Intranuclear Inclusion Disease: A Case Report
AU  - Tomoya Inaba
AU  - Yoshinori Hirata
AU  - Hidehiro Ishikawa
AU  - Asako Tamura
AU  - Jun Sone
AU  - Akihiro Shindo
PY  - 2026
DA  - 2026/07/04
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7301-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7301-26/_article
AB  - An 81-year-old woman was transferred to our hospital due to a consciousness disorder. MRI of her cranium revealed white matter lesions and lesions in the cerebellar paravermis, splenium of the corpus callosum, and a left temporal pole on fluid-attenuated inversion recovery (FLAIR) sequences. Diffusion-weighted imaging (DWI) revealed hyperintensity at the left frontal corticomedullary junction of the brain. She was diagnosed with neuronal intranuclear inclusion disease (NIID) via a skin biopsy and genetic analysis. These lesions were evident before the DWI hyperintensity was clear. When a lesion in the temporal pole is observed, then NIID should be considered in the differential diagnosis.
SN  - 1349-7235
SN  - 0918-2918
ER  -