Peer-reviewedCC BYSTAR protocols
Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.
- 1Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
- 2SONELE Inc., Markham, ON, Canada.
- 3Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: [email protected].
Abstract
Focused ultrasound (FUS) enables non-invasive, spatially precise modulation of biological tissues. This protocol describes assembly, calibration, and implementation of a diagnostic ultrasound-guided FUS (dUS-FUS) platform for real-time targeting of superficial and deep tissues in small-animal models. We demonstrate reversible sciatic nerve modulation in a rat acute pain model and assess sensory and motor functions using behavioral tests. The platform provides a reproducible workflow for image-guided tissue modulation and can be adapted to diverse preclinical applications. For complete details on the use and execution of this protocol, please refer to Sangwan et al.¹,².
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BibTeX
@article{sangwan2026imageguided,
title = {{Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.}},
author = {Namrata Sangwan and N Chris Chaggares and Zahra Torbatian and Thomas Anthony Anderson},
journal = {STAR protocols},
year = {2026},
month = oct,
doi = {10.1016/j.xpro.2026.104900},
url = {https://europepmc.org/article/MED/42895854},
note = {CC BY},
}
RIS
TY - JOUR
TI - Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.
AU - Namrata Sangwan
AU - N Chris Chaggares
AU - Zahra Torbatian
AU - Thomas Anthony Anderson
PY - 2026
DA - 2026/10/19
JO - STAR protocols
DO - 10.1016/j.xpro.2026.104900
UR - https://europepmc.org/article/MED/42895854
AB - Focused ultrasound (FUS) enables non-invasive, spatially precise modulation of biological tissues. This protocol describes assembly, calibration, and implementation of a diagnostic ultrasound-guided FUS (dUS-FUS) platform for real-time targeting of superficial and deep tissues in small-animal models. We demonstrate reversible sciatic nerve modulation in a rat acute pain model and assess sensory and motor functions using behavioral tests. The platform provides a reproducible workflow for image-guided tissue modulation and can be adapted to diverse preclinical applications. For complete details on the use and execution of this protocol, please refer to Sangwan et al.¹,².
SN - 2666-1667
ER -