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Peer-reviewedCC BY-NC-NDClinical case reports

Hydroxychloroquine‐Associated Renal Phospholipidosis: A Forgotten Complication of a Common Drug

  • Yu‐Chien Tsao1
  • Chun‐Hsin Wu1,2
  1. 1Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan
  2. 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan
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Abstract

Hydroxychloroquine (HCQ) treatment in systemic lupus erythematosus can induce drug‐induced phospholipidosis mimicking Fabry disease. A 32‐year‐old woman with lupus nephritis developed podocyte “zebra bodies” on electron microscopy. Normal lyso‐Gb3 excluded Fabry disease, confirming HCQ toxicity. Discontinuation and immunosuppression yielded stable renal function and improved proteinuria.

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Cite

BibTeXRIS
BibTeX
@article{tsao2026hydroxychloroquineassociated,
  title = {{Hydroxychloroquine‐Associated Renal Phospholipidosis: A Forgotten Complication of a Common Drug}},
  author = {Yu‐Chien Tsao and Chun‐Hsin Wu},
  journal = {Clinical case reports},
  year = {2026},
  month = nov,
  doi = {10.1002/ccr3.73874},
  url = {https://europepmc.org/article/PMC/PMC13725595},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Hydroxychloroquine‐Associated Renal Phospholipidosis: A Forgotten Complication of a Common Drug
AU  - Yu‐Chien Tsao
AU  - Chun‐Hsin Wu
PY  - 2026
DA  - 2026/11/01
JO  - Clinical case reports
DO  - 10.1002/ccr3.73874
UR  - https://europepmc.org/article/PMC/PMC13725595
AB  - Hydroxychloroquine (HCQ) treatment in systemic lupus erythematosus can induce drug‐induced phospholipidosis mimicking Fabry disease. A 32‐year‐old woman with lupus nephritis developed podocyte “zebra bodies” on electron microscopy. Normal lyso‐Gb3 excluded Fabry disease, confirming HCQ toxicity. Discontinuation and immunosuppression yielded stable renal function and improved proteinuria.
SN  - 2050-0904
ER  -