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Peer-reviewedCC BYFrontiers in ophthalmology

Structural changes in the retinal layers of patients with Steinert disease.

  • Beatriz Cordón1,2
  • Beatriz Pardiñas3
  • Mónica Hernández4,5
  • María Jesús Rodrigo1,2
  • Elvira Mayordomo4,5
  • Luis Emilio Pablo1,2
  • Elena García-Martin1,2
5 affiliations
  1. 1Miguel Servet Ophthalmology Research and Innovation Group (GIMSO), Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Zaragoza, Spain.
  2. 2Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.
  3. 3Department of Neurology, Miguel Servet University Hospital, Zaragoza, Spain.
  4. 4Department of Computer Science, University of Zaragoza, Zaragoza, Spain.
  5. 5Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.
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Abstract

Purpose

The purpose of this study was to evaluate the different retinal layers of the posterior pole protocol and peripapillary areas in optical coherence tomography (OCT) to identify significant changes attributable to Steinert disease.Methods

We analyzed 128 eyes of healthy control subjects and 79 eyes of patients with Steinert disease. We performed the posterior pole and Nsite analytics peripapillary protocols on all subjects and compared thicknesses in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), and complete retina (RETINA).Results

Patients with Steinert disease showed significant alterations in retinal layer thickness compared with age-matched controls. Overall, a generalized thickening of retinal layers was observed; significant thickening of the RNFL was also found in the temporal area of the optic nerve and in the papillomacular bundle, which comprises the retinal ganglion cell axons connecting the macula with the optic nerve.Conclusions

Steinert disease is associated with retinal structural alterations in retinal layer structure, OCT may provide potential structural markers of retinal involvement in Steinert disease.

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Cite

BibTeXRIS
BibTeX
@article{cordon2026structural,
  title = {{Structural changes in the retinal layers of patients with Steinert disease.}},
  author = {Beatriz Cordón and Beatriz Pardiñas and Mónica Hernández and María Jesús Rodrigo and Elvira Mayordomo and Luis Emilio Pablo and Elena García-Martin},
  journal = {Frontiers in ophthalmology},
  year = {2026},
  month = oct,
  doi = {10.3389/fopht.2026.1959492},
  url = {https://europepmc.org/article/MED/42908507},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Structural changes in the retinal layers of patients with Steinert disease.
AU  - Beatriz Cordón
AU  - Beatriz Pardiñas
AU  - Mónica Hernández
AU  - María Jesús Rodrigo
AU  - Elvira Mayordomo
AU  - Luis Emilio Pablo
AU  - Elena García-Martin
PY  - 2026
DA  - 2026/10/07
JO  - Frontiers in ophthalmology
DO  - 10.3389/fopht.2026.1959492
UR  - https://europepmc.org/article/MED/42908507
AB  - Purpose  The purpose of this study was to evaluate the different retinal layers of the posterior pole protocol and peripapillary areas in optical coherence tomography (OCT) to identify significant changes attributable to Steinert disease.Methods  We analyzed 128 eyes of healthy control subjects and 79 eyes of patients with Steinert disease. We performed the posterior pole and Nsite analytics peripapillary protocols on all subjects and compared thicknesses in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), and complete retina (RETINA).Results  Patients with Steinert disease showed significant alterations in retinal layer thickness compared with age-matched controls. Overall, a generalized thickening of retinal layers was observed; significant thickening of the RNFL was also found in the temporal area of the optic nerve and in the papillomacular bundle, which comprises the retinal ganglion cell axons connecting the macula with the optic nerve.Conclusions  Steinert disease is associated with retinal structural alterations in retinal layer structure, OCT may provide potential structural markers of retinal involvement in Steinert disease.
SN  - 2674-0826
ER  -