Peer-reviewedCC BY-NCBeyoglu eye journal1 Oct 2026

A Clinical Study of Retinal Nerve Fibre Layer and Ganglion Cell Layer changes in patients with Migraine at a Tertiary Care Hospital.

Tanvi Shetty¹
Thanuja Gopal Pradeep¹
Pradeep Rangaiah²

¹Department of Ophthalmology, Ramaiah University of Applied Sciences, Ramaiah Medical College, Bangalore, India.
²Department of Neurology, , Ramaiah University of Applied Sciences, Ramaiah Medical College, Bangalore, India.

Abstract

Objective

This study aimed to assess and compare retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness in migraine patients versus controls and to analyze differences between chronic and episodic migraine.Methods

A cross-sectional, case-control study was conducted from June 2022 to December 2023. A total of 100 migraine patients (33 chronic, 67 episodic) and 102 controls underwent detailed ocular evaluation using OCT. RNFL and GCL parameters were compared between cases and controls using an independent t-test. Paired t-tests assessed differences between chronic and episodic migraine, as well as between the right and left eyes.Results

Photophobia (90%) and ocular pain (85%) were the most common symptoms. Migraine patients showed a significant reduction in average (106 µm), superior (129 µm), and nasal (80 µm) RNFL thickness compared to controls. Chronic migraine patients exhibited significant thinning in the temporal (67 µm) and nasal (72 µm) RNFL quadrants and superotemporal (67 µm) and superonasal (70 µm) GCL quadrants in the right eye. Episodic migraine patients had reduced superotemporal GCL thickness (71 µm) in the left eye.Conclusion

The retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness is reduced in chronic and episodic type of migraine patients. Hence, ophthalmologists should consider the potential impact of migraine headaches on the thickness of RNFL and GCL.

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BibTeX RIS

BibTeX

@article{shetty2026clinical,
  title = {{A Clinical Study of Retinal Nerve Fibre Layer and Ganglion Cell Layer changes in patients with Migraine at a Tertiary Care Hospital.}},
  author = {Tanvi Shetty and Thanuja Gopal Pradeep and Pradeep Rangaiah},
  journal = {Beyoglu eye journal},
  year = {2026},
  month = oct,
  doi = {10.14744/bej.2026.82652},
  url = {https://europepmc.org/article/MED/42898759},
  note = {CC BY-NC},
}

RIS

TY  - JOUR
TI  - A Clinical Study of Retinal Nerve Fibre Layer and Ganglion Cell Layer changes in patients with Migraine at a Tertiary Care Hospital.
AU  - Tanvi Shetty
AU  - Thanuja Gopal Pradeep
AU  - Pradeep Rangaiah
PY  - 2026
DA  - 2026/10/01
JO  - Beyoglu eye journal
DO  - 10.14744/bej.2026.82652
UR  - https://europepmc.org/article/MED/42898759
AB  - Objective  This study aimed to assess and compare retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness in migraine patients versus controls and to analyze differences between chronic and episodic migraine.Methods  A cross-sectional, case-control study was conducted from June 2022 to December 2023. A total of 100 migraine patients (33 chronic, 67 episodic) and 102 controls underwent detailed ocular evaluation using OCT. RNFL and GCL parameters were compared between cases and controls using an independent t-test. Paired t-tests assessed differences between chronic and episodic migraine, as well as between the right and left eyes.Results  Photophobia (90%) and ocular pain (85%) were the most common symptoms. Migraine patients showed a significant reduction in average (106 µm), superior (129 µm), and nasal (80 µm) RNFL thickness compared to controls. Chronic migraine patients exhibited significant thinning in the temporal (67 µm) and nasal (72 µm) RNFL quadrants and superotemporal (67 µm) and superonasal (70 µm) GCL quadrants in the right eye. Episodic migraine patients had reduced superotemporal GCL thickness (71 µm) in the left eye.Conclusion  The retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thickness is reduced in chronic and episodic type of migraine patients. Hence, ophthalmologists should consider the potential impact of migraine headaches on the thickness of RNFL and GCL.
SN  - 2459-1777
SN  - 2587-0394
ER  -

Abstract

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