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Peer-reviewedCC BYScientific Reports

Trends and characteristics of major salivary gland carcinoma incidence in the United States, 2000–2022

  • Dongbin Ahn1
  • Theresa Guo2
  • Jingjing Hu3
  • Tomoya Kurokawa4
  • Joseph Califano2
4 affiliations
  1. 1Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University
  2. 2Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of California San Diego
  3. 3Department of Pathology, School of Medicine, University of California San Diego
  4. 4Moores Cancer Center, University of California San Diego
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Abstract

This study analyzed contemporary trends in major salivary gland carcinoma (MSGC) incidence in the United States from 2000 to 2022 using the SEER 17 Registries. Age-adjusted incidence rates (IRs) per 1,000,000 persons and temporal trends were evaluated using annual percent change (APC) and average APC (AAPC). A total of 20,522 MSGC cases were identified, with an overall IR of 10.4 and a significant increasing trend over time (APC = 0.42%, P = 0.015). Incidence increased particularly among females (APC = 0.81%, P = 0.002), older age groups (60–79 years: APC = 0.40%, P = 0.036; ≥80 years: APC = 1.12%, P = 0.010), the Black population (APC = 0.80%, P = 0.029), and parotid gland primaries (APC = 0.40%, P = 0.023). In stage-specific analyses restricted to 2004–2022, localized disease also increased significantly (APC = 0.89%, P = 0.002). Among major histologic subtypes, adenocarcinoma, not otherwise specified, showed a significant decreasing trend (AAPC=–3.33%, P < 0.001), whereas salivary duct carcinoma (AAPC = 10.41%, P < 0.001) and carcinoma ex pleomorphic adenoma (APC = 2.20%, P = 0.022) showed increasing trends. Female-focused subgroup analyses demonstrated increasing incidence in both age groups: females aged ≥ 60 years (APC = 0.64%, P = 0.012) and those aged < 60 years (APC = 0.88%, P = 0.009). Mucoepidermoid carcinoma also exhibited an increasing trend among females (APC = 0.87%, P = 0.016). These findings indicate a significant increase in MSGC incidence in the US, with distinct demographic and clinicopathological patterns.

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Cite

BibTeXRIS
BibTeX
@article{ahn2026trends,
  title = {{Trends and characteristics of major salivary gland carcinoma incidence in the United States, 2000–2022}},
  author = {Dongbin Ahn and Theresa Guo and Jingjing Hu and Tomoya Kurokawa and Joseph Califano},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-62829-0},
  url = {https://doi.org/10.1038/s41598-026-62829-0},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Trends and characteristics of major salivary gland carcinoma incidence in the United States, 2000–2022
AU  - Dongbin Ahn
AU  - Theresa Guo
AU  - Jingjing Hu
AU  - Tomoya Kurokawa
AU  - Joseph Califano
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-62829-0
UR  - https://doi.org/10.1038/s41598-026-62829-0
AB  - This study analyzed contemporary trends in major salivary gland carcinoma (MSGC) incidence in the United States from 2000 to 2022 using the SEER 17 Registries. Age-adjusted incidence rates (IRs) per 1,000,000 persons and temporal trends were evaluated using annual percent change (APC) and average APC (AAPC). A total of 20,522 MSGC cases were identified, with an overall IR of 10.4 and a significant increasing trend over time (APC = 0.42%, P = 0.015). Incidence increased particularly among females (APC = 0.81%, P = 0.002), older age groups (60–79 years: APC = 0.40%, P = 0.036; ≥80 years: APC = 1.12%, P = 0.010), the Black population (APC = 0.80%, P = 0.029), and parotid gland primaries (APC = 0.40%, P = 0.023). In stage-specific analyses restricted to 2004–2022, localized disease also increased significantly (APC = 0.89%, P = 0.002). Among major histologic subtypes, adenocarcinoma, not otherwise specified, showed a significant decreasing trend (AAPC=–3.33%, P < 0.001), whereas salivary duct carcinoma (AAPC = 10.41%, P < 0.001) and carcinoma ex pleomorphic adenoma (APC = 2.20%, P = 0.022) showed increasing trends. Female-focused subgroup analyses demonstrated increasing incidence in both age groups: females aged ≥ 60 years (APC = 0.64%, P = 0.012) and those aged < 60 years (APC = 0.88%, P = 0.009). Mucoepidermoid carcinoma also exhibited an increasing trend among females (APC = 0.87%, P = 0.016). These findings indicate a significant increase in MSGC incidence in the US, with distinct demographic and clinicopathological patterns.
SN  - 2045-2322
ER  -