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Peer-reviewedCC BY 4.0ACS Omega

Synthesis and Biological Activity of Iminophosphine Copper(I) Complexes Derived from 2-(Diphenylphosphino)benzaldehyde and 4-Substituted-Benzylamines

  • Alessio Zavaroni1
  • Luca Rigamonti2
  • Giorgio Pelosi1
  • Lorenzo Verderi1
  • Matteo Incerti3
  • Lisa Menegaldo4
  • Diego Montagner5
  • Dominga Rogolino1
  • Francesca Bonvicini4
  • Mauro Carcelli1
5 affiliations
  1. 1University of Parma , , Parco Area delle Scienze 11/A , ,
  2. 2Università di Modena e Reggio Emilia , , via G. Campi 103 , ,
  3. 3University of Parma , , Parco Area delle Scienze 27/A , ,
  4. 4University of Bologna , , Via Massarenti 9 , ,
  5. 5Maynooth University , , ,
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Abstract

A panel of copper(I) complexes was isolated by metal-templated reactions starting from 2-(diphenylphosphino)benzaldehyde and some 4-substituted-benzylamines, and by changing the ratio between metal and ligand and the anion. The spectroscopic characterization of the copper(I) complexes was completed by discussion of some structures obtained by single-crystal X-ray diffraction. The copper(I) complexes were assayed in vitro against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. Cell viability was assessed both in nonmalignant and malignant cell lines, namely Vero and Caco-2 cells, respectively. While the tested compounds show only a nonspecific antibacterial effect against S. aureus, some of them showed an interesting antiproliferative activity.

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Cite

BibTeXRIS
BibTeX
@article{zavaroni2026synthesis,
  title = {{Synthesis and Biological Activity of Iminophosphine Copper(I) Complexes Derived from 2-(Diphenylphosphino)benzaldehyde and 4-Substituted-Benzylamines}},
  author = {Alessio Zavaroni and Luca Rigamonti and Giorgio Pelosi and Lorenzo Verderi and Matteo Incerti and Lisa Menegaldo and Diego Montagner and Dominga Rogolino and Francesca Bonvicini and Mauro Carcelli},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c08107},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08107/5459776/Synthesis-and-Biological-Activity-of},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Synthesis and Biological Activity of Iminophosphine Copper(I) Complexes Derived from 2-(Diphenylphosphino)benzaldehyde and 4-Substituted-Benzylamines
AU  - Alessio Zavaroni
AU  - Luca Rigamonti
AU  - Giorgio Pelosi
AU  - Lorenzo Verderi
AU  - Matteo Incerti
AU  - Lisa Menegaldo
AU  - Diego Montagner
AU  - Dominga Rogolino
AU  - Francesca Bonvicini
AU  - Mauro Carcelli
PY  - 2026
DA  - 2026/10/28
JO  - ACS Omega
DO  - 10.1021/acsomega.6c08107
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08107/5459776/Synthesis-and-Biological-Activity-of
AB  - A panel of copper(I) complexes was isolated by metal-templated reactions starting from 2-(diphenylphosphino)benzaldehyde and some 4-substituted-benzylamines, and by changing the ratio between metal and ligand and the anion. The spectroscopic characterization of the copper(I) complexes was completed by discussion of some structures obtained by single-crystal X-ray diffraction. The copper(I) complexes were assayed in vitro against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. Cell viability was assessed both in nonmalignant and malignant cell lines, namely Vero and Caco-2 cells, respectively. While the tested compounds show only a nonspecific antibacterial effect against S. aureus, some of them showed an interesting antiproliferative activity.
SN  - 2470-1343
ER  -