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Peer-reviewedCC BY 4.0Nanomaterials

Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes

  • Almudena Marti
  • Jurriaan Huskens
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Abstract

Affinity sensing of nucleic acids is among the most investigated areas in biosensing due to the growing importance of DNA diagnostics in healthcare research and clinical applications. Here, we report a simple electrochemical DNA detection layer, based on poly-l-lysine (PLL), in combination with gold nanoparticles (AuNPs) as a signal amplifier. The layer shows excellent reduction of non-specific binding and thereby high contrast between amplified and non-amplified signals with functionalized AuNPs; the relative change in current was 10-fold compared to the non-amplified signal. The present work may provide a general method for the detection of tumor markers based on electrochemical DNA sensing.

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Cite

BibTeXRIS
BibTeX
@article{marti2026nanoparticlebased,
  title = {{Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes}},
  author = {Almudena Marti and Jurriaan Huskens},
  journal = {Nanomaterials},
  year = {2026},
  month = sep,
  doi = {10.3390/nano12020242},
  url = {https://hal.univ-lorraine.fr/hal-03562538v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes
AU  - Almudena Marti
AU  - Jurriaan Huskens
PY  - 2026
DA  - 2026/09/09
JO  - Nanomaterials
DO  - 10.3390/nano12020242
UR  - https://hal.univ-lorraine.fr/hal-03562538v1
AB  - Affinity sensing of nucleic acids is among the most investigated areas in biosensing due to the growing importance of DNA diagnostics in healthcare research and clinical applications. Here, we report a simple electrochemical DNA detection layer, based on poly-l-lysine (PLL), in combination with gold nanoparticles (AuNPs) as a signal amplifier. The layer shows excellent reduction of non-specific binding and thereby high contrast between amplified and non-amplified signals with functionalized AuNPs; the relative change in current was 10-fold compared to the non-amplified signal. The present work may provide a general method for the detection of tumor markers based on electrochemical DNA sensing.
SN  - 2079-4991
SN  - 2079-4991
ER  -