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Peer-reviewedCC BY-NC-NDMaterials today. Bio

Coordination-strengthened Rhein/Pectin@Zn dual-network hydrogel for local antitumor therapy.

  • Kai Li1,2
  • Qili Sun1
  • Jingle Chen3
  • YanSong Wang1
  • Enze Zhao1
  • Shuaishuai Cao4
  • Chao Xie3
  • Bin Tang1,5
5 affiliations
  1. 1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China.
  2. 2Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, PR China.
  3. 3Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.
  4. 4Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, PR China.
  5. 5Guangdong Provincial Key Laboratory of Advanced Biomaterials, PR China.
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Abstract

Local therapeutic platforms capable of concurrent tumor-cell elimination and antiangiogenic activity are urgently needed. This study presents a Rhein/Pectin@Zn hydrogel fabricated through supramolecular self-assembly and metal-coordination crosslinking and administered by dual-syringe in situ gelation. Hydrogels prepared under standardized ex vivo crosslinking conditions display a porous microstructure, stable gel characteristics, shear-dependent flow behavior, and accelerated cargo release under acidic conditions. Biological evaluations indicate antiproliferative and pro-apoptotic effects against tumor cells, together with reduced endothelial angiogenic signaling. Repeated intratumoral delivery in a subcutaneous B16 melanoma model reduced endpoint tumor volume and weight without overt major-organ histopathological abnormalities in the displayed fields. Integrated transcriptomic and molecular analyses implicated cell-cycle checkpoint disruption and apoptosis-associated signaling in the observed antitumor response. Collectively, this work positions Rhein/Pectin@Zn as an in situ-forming hydrogel for local cancer therapy.

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Cite

BibTeXRIS
BibTeX
@article{li2026coordinationstrengthened,
  title = {{Coordination-strengthened Rhein/Pectin@Zn dual-network hydrogel for local antitumor therapy.}},
  author = {Kai Li and Qili Sun and Jingle Chen and YanSong Wang and Enze Zhao and Shuaishuai Cao and Chao Xie and Bin Tang},
  journal = {Materials today. Bio},
  year = {2026},
  month = oct,
  doi = {10.1016/j.mtbio.2026.103733},
  url = {https://europepmc.org/article/MED/42910188},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Coordination-strengthened Rhein/Pectin@Zn dual-network hydrogel for local antitumor therapy.
AU  - Kai Li
AU  - Qili Sun
AU  - Jingle Chen
AU  - YanSong Wang
AU  - Enze Zhao
AU  - Shuaishuai Cao
AU  - Chao Xie
AU  - Bin Tang
PY  - 2026
DA  - 2026/10/07
JO  - Materials today. Bio
DO  - 10.1016/j.mtbio.2026.103733
UR  - https://europepmc.org/article/MED/42910188
AB  - Local therapeutic platforms capable of concurrent tumor-cell elimination and antiangiogenic activity are urgently needed. This study presents a Rhein/Pectin@Zn hydrogel fabricated through supramolecular self-assembly and metal-coordination crosslinking and administered by dual-syringe in situ gelation. Hydrogels prepared under standardized ex vivo crosslinking conditions display a porous microstructure, stable gel characteristics, shear-dependent flow behavior, and accelerated cargo release under acidic conditions. Biological evaluations indicate antiproliferative and pro-apoptotic effects against tumor cells, together with reduced endothelial angiogenic signaling. Repeated intratumoral delivery in a subcutaneous B16 melanoma model reduced endpoint tumor volume and weight without overt major-organ histopathological abnormalities in the displayed fields. Integrated transcriptomic and molecular analyses implicated cell-cycle checkpoint disruption and apoptosis-associated signaling in the observed antitumor response. Collectively, this work positions Rhein/Pectin@Zn as an in situ-forming hydrogel for local cancer therapy.
SN  - 2590-0064
ER  -