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Peer-reviewedCC BY-NC-NDJournal of medical case reports

Molecular clues to the rescue: differentiating gestational and non-gestational ovarian choriocarcinoma-a case report.

  • Ritwika Choudhury1
  • Mansi Sharma1
  • Bhumi Agarwal1
  • Priyanka Venkataraman2
  • Ullas Batra3
  1. 1Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Sector 5, Rohini, New Delhi, 110085, India.
  2. 2Department of Research Medical Unit 5, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India.
  3. 3Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Sector 5, Rohini, New Delhi, 110085, India. [email protected].
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Abstract

Background

Non-gestational ovarian choriocarcinoma (NGOC) is a rare and aggressive tumor. Distinguishing NGOC from its gestational counterpart especially in the reproductive age group often presents as a diagnostic challenge. The treatment and prognoses of both differ significantly. Molecular methods are gold standard and should be used in establishing an accurate diagnosis is such cases.Case presentation

A sexually active 22-year-old Indian female presented with irregular menstrual cycles and abdominal pain. Imaging revealed a right ovarian mass with liver and lung metastases. She underwent surgical resection of the ovarian tumor. Histopathology suggested choriocarcinoma, and molecular analysis using a PCR-based assay confirmed the absence of Y chromosome DNA, establishing the diagnosis of NGOC. She received BEP chemotherapy and showed a complete metabolic response and is currently on follow-up.Conclusions

This case highlights the critical role of molecular diagnostics in differentiating NGOC from GOC. It also emphasizes the importance of early diagnosis and timely initiation of appropriate chemotherapy in achieving favorable outcomes in this rare but potentially curable malignancy.

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Cite

BibTeXRIS
BibTeX
@article{choudhury2026molecular,
  title = {{Molecular clues to the rescue: differentiating gestational and non-gestational ovarian choriocarcinoma-a case report.}},
  author = {Ritwika Choudhury and Mansi Sharma and Bhumi Agarwal and Priyanka Venkataraman and Ullas Batra},
  journal = {Journal of medical case reports},
  year = {2026},
  month = aug,
  doi = {10.1186/s13256-026-06427-8},
  url = {https://europepmc.org/article/MED/42958320},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Molecular clues to the rescue: differentiating gestational and non-gestational ovarian choriocarcinoma-a case report.
AU  - Ritwika Choudhury
AU  - Mansi Sharma
AU  - Bhumi Agarwal
AU  - Priyanka Venkataraman
AU  - Ullas Batra
PY  - 2026
DA  - 2026/08/02
JO  - Journal of medical case reports
DO  - 10.1186/s13256-026-06427-8
UR  - https://europepmc.org/article/MED/42958320
AB  - Background  Non-gestational ovarian choriocarcinoma (NGOC) is a rare and aggressive tumor. Distinguishing NGOC from its gestational counterpart especially in the reproductive age group often presents as a diagnostic challenge. The treatment and prognoses of both differ significantly. Molecular methods are gold standard and should be used in establishing an accurate diagnosis is such cases.Case presentation  A sexually active 22-year-old Indian female presented with irregular menstrual cycles and abdominal pain. Imaging revealed a right ovarian mass with liver and lung metastases. She underwent surgical resection of the ovarian tumor. Histopathology suggested choriocarcinoma, and molecular analysis using a PCR-based assay confirmed the absence of Y chromosome DNA, establishing the diagnosis of NGOC. She received BEP chemotherapy and showed a complete metabolic response and is currently on follow-up.Conclusions  This case highlights the critical role of molecular diagnostics in differentiating NGOC from GOC. It also emphasizes the importance of early diagnosis and timely initiation of appropriate chemotherapy in achieving favorable outcomes in this rare but potentially curable malignancy.
SN  - 1752-1947
ER  -