Interplay among neural synchronization, excitability, variability, and sequentiality across time scales in rhythmic bursting
Abstract
Rhythmic neural activity in the form of robust sequential activations is present in many neural systems at multiple description levels. Circuits generating such activity often involve intrinsic neuronal variability and interactions mediated by distinct synapse types. The control of sequential rhythms requires coordination across short and intermediate time scales to adapt to conditions within each cycle of the rhythm or to adjust excitability and speed to meet specific functional demands. In this work we analyze the interplay among neural synchronization, excitability, variability and sequentiality timing in rhythmic bursting. We analyze long intracellular and extracellular recordings of the pyloric CPG quantifying these aspects and reporting their relationships at multiple time scales including the modulation of cycle-by-cycle sequential dynamical invariants among key time intervals. The results of the relationship between specific sequence intervals at different time scales provide a novel view on the understanding of autonomous motor coordination in robust, yet time-flexible sequential rhythms, even during transient dynamics.
Related
- Awake sharp-wave ripples coincide with rhythmic cortical synchronization
- Brain–Environment Rhythmic Coupling: An Interdisciplinary Review of Rhythm Synchronization between the brain and the environment
- Interplay between Excitability and Noise in Analog Spiking Neurons
- Rhythmic-phasic c-di-AMP signaling: a new paradigm for bacterial growth synchronization governed by a pseudo-phosphodiesterase and modifiable diadenylate cyclase.
- Quantifying Event-Related (De)Synchronization Variability for Brain-Computer Interface: A Unified and Interpretable Framework
BibTeX
@article{sanchezmartin2026interplay,
title = {{Interplay among neural synchronization, excitability, variability, and sequentiality across time scales in rhythmic bursting}},
author = {Pablo Sanchez-Martin and Alicia Garrido-Peña and Irene Elices and Carlos Garcia-Saura and Rafael Levi and Francisco B. Rodríguez and Pablo Varona},
journal = {Scientific Reports},
year = {2026},
month = oct,
doi = {10.1038/s41598-026-73759-2},
url = {https://www.nature.com/articles/s41598-026-73759-2},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Interplay among neural synchronization, excitability, variability, and sequentiality across time scales in rhythmic bursting
AU - Pablo Sanchez-Martin
AU - Alicia Garrido-Peña
AU - Irene Elices
AU - Carlos Garcia-Saura
AU - Rafael Levi
AU - Francisco B. Rodríguez
AU - Pablo Varona
PY - 2026
DA - 2026/10/08
JO - Scientific Reports
DO - 10.1038/s41598-026-73759-2
UR - https://www.nature.com/articles/s41598-026-73759-2
AB - Rhythmic neural activity in the form of robust sequential activations is present in many neural systems at multiple description levels. Circuits generating such activity often involve intrinsic neuronal variability and interactions mediated by distinct synapse types. The control of sequential rhythms requires coordination across short and intermediate time scales to adapt to conditions within each cycle of the rhythm or to adjust excitability and speed to meet specific functional demands. In this work we analyze the interplay among neural synchronization, excitability, variability and sequentiality timing in rhythmic bursting. We analyze long intracellular and extracellular recordings of the pyloric CPG quantifying these aspects and reporting their relationships at multiple time scales including the modulation of cycle-by-cycle sequential dynamical invariants among key time intervals. The results of the relationship between specific sequence intervals at different time scales provide a novel view on the understanding of autonomous motor coordination in robust, yet time-flexible sequential rhythms, even during transient dynamics.
SN - 2045-2322
ER -