Hyaluronic Acid-Based Nanoplatforms for Photoacoustic Monitoring of Phototherapy
- 1Department of Cogno-Mechatronics Engineering, School of Transdisciplinary Engineering, Pusan National University, Busan 46241, Republic of Korea
- 2Department of Biomedical Engineering and Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
- 3Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea
Abstract
Photoacoustic imaging is a noninvasive imaging modality with considerable potential for theranostic applications, providing high-resolution visualization of molecular and physiological responses to treatment. Among the diverse materials investigated for constructing theranostic nanoplatforms, hyaluronic acid has attracted substantial interest because of its biocompatibility, hydrophilicity, chemical modifiability, and affinity for CD44 receptors, which are frequently overexpressed in various cancer cells. Moreover, appropriately engineered hyaluronic acid-based formulations offer opportunities for localized and transdermal delivery, potentially reducing the need for systemic administration and expanding the applicability of noninvasive phototherapy, particularly for superficial lesions. In this review, we summarize recent advances in hyaluronic acid-based nanoplatforms for photoacoustic imaging-monitored phototherapy, categorized into photothermal therapy, photodynamic therapy, and their combination. We further discuss their material design, targeting and delivery mechanisms, photoacoustic monitoring capabilities, therapeutic performance, and key challenges for clinical translation.
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BibTeX
@article{jeong2026hyaluronic,
title = {{Hyaluronic Acid-Based Nanoplatforms for Photoacoustic Monitoring of Phototherapy}},
author = {Yongjae Jeong and Dongyoung Jo and Wonseok Choi and Ki Su Kim and Jeesu Kim},
journal = {Biomolecules},
year = {2026},
month = oct,
doi = {10.3390/biom16101509},
url = {https://www.mdpi.com/2218-273X/16/10/1509},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Hyaluronic Acid-Based Nanoplatforms for Photoacoustic Monitoring of Phototherapy
AU - Yongjae Jeong
AU - Dongyoung Jo
AU - Wonseok Choi
AU - Ki Su Kim
AU - Jeesu Kim
PY - 2026
DA - 2026/10/01
JO - Biomolecules
DO - 10.3390/biom16101509
UR - https://www.mdpi.com/2218-273X/16/10/1509
AB - Photoacoustic imaging is a noninvasive imaging modality with considerable potential for theranostic applications, providing high-resolution visualization of molecular and physiological responses to treatment. Among the diverse materials investigated for constructing theranostic nanoplatforms, hyaluronic acid has attracted substantial interest because of its biocompatibility, hydrophilicity, chemical modifiability, and affinity for CD44 receptors, which are frequently overexpressed in various cancer cells. Moreover, appropriately engineered hyaluronic acid-based formulations offer opportunities for localized and transdermal delivery, potentially reducing the need for systemic administration and expanding the applicability of noninvasive phototherapy, particularly for superficial lesions. In this review, we summarize recent advances in hyaluronic acid-based nanoplatforms for photoacoustic imaging-monitored phototherapy, categorized into photothermal therapy, photodynamic therapy, and their combination. We further discuss their material design, targeting and delivery mechanisms, photoacoustic monitoring capabilities, therapeutic performance, and key challenges for clinical translation.
SN - 2218-273X
ER -