Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing
Abstract
Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingredients. One of the key challenges in AFDs is associated with undesired agglomeration, where the presence of hard agglomerates results in off-spec products, equipment damage, and additional downstream processing. This article presents a novel mechanistic model that describes the formation of soft and hard agglomerates during agitated filter drying. By integrating population balance and multiphysics modeling, the model can accurately predict the evolution of the product temperature, moisture content, and particle size distribution, and hence quantify the extend and impact of undesired agglomeration across various operating conditions. Our proposed model-based framework enables the rational design and operation of AFDs for improving the product quality and process reliability.
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BibTeX
@misc{srisuma2026integrated,
title = {{Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing}},
author = {Prakitr Srisuma and Peter Hou and Shashank Venkat Muddu and Neda Nazemifard and Allan S. Myerson and Richard D. Braatz},
howpublished = {arXiv},
year = {2026},
month = sep,
doi = {10.48550/arxiv.2609.10256},
eprint = {2609.10256},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2609.10256},
}
RIS
TY - UNPB
TI - Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing
AU - Prakitr Srisuma
AU - Peter Hou
AU - Shashank Venkat Muddu
AU - Neda Nazemifard
AU - Allan S. Myerson
AU - Richard D. Braatz
PY - 2026
DA - 2026/09/09
PB - arXiv
DO - 10.48550/arxiv.2609.10256
UR - https://arxiv.org/abs/2609.10256
AB - Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingredients. One of the key challenges in AFDs is associated with undesired agglomeration, where the presence of hard agglomerates results in off-spec products, equipment damage, and additional downstream processing. This article presents a novel mechanistic model that describes the formation of soft and hard agglomerates during agitated filter drying. By integrating population balance and multiphysics modeling, the model can accurately predict the evolution of the product temperature, moisture content, and particle size distribution, and hence quantify the extend and impact of undesired agglomeration across various operating conditions. Our proposed model-based framework enables the rational design and operation of AFDs for improving the product quality and process reliability.
ER -