Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph
- 1Department of Psychiatry, University of Tsukuba Hospital
Abstract
Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolved the canonical CTE Type I structure and a previously unreported CTE Type I-like structure with a shifted protofilament interface at 2.78 and 2.96 A, respectively. Mapping particle-state assignments back onto the original micrographs showed that the CTE Type I and CTE Type I-like packing states can occupy locally contiguous regions within the same fibrils. These findings identify an interface-shifted CTE Type I-like structure and support its local coexistence with CTE Type I within individual fibrils.
Versions
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BibTeX
@misc{watanabe2026structural,
title = {{Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph}},
author = {R. Watanabe and E. B. Lee},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.10.750773},
url = {https://www.biorxiv.org/content/10.64898/2026.09.10.750773v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph
AU - R. Watanabe
AU - E. B. Lee
PY - 2026
DA - 2026/09/10
PB - bioRxiv
DO - 10.64898/2026.09.10.750773
UR - https://www.biorxiv.org/content/10.64898/2026.09.10.750773v1
AB - Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolved the canonical CTE Type I structure and a previously unreported CTE Type I-like structure with a shifted protofilament interface at 2.78 and 2.96 A, respectively. Mapping particle-state assignments back onto the original micrographs showed that the CTE Type I and CTE Type I-like packing states can occupy locally contiguous regions within the same fibrils. These findings identify an interface-shifted CTE Type I-like structure and support its local coexistence with CTE Type I within individual fibrils.
ER -