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Peer-reviewedCC BY 4.0Cureus

Unveiling Kaposi Sarcoma: A Case Report on the Clinical Journey in an HIV-Infected Patient

  • Tzipora Levitt1
  • Amy Chen1
  • Jonathan Shadan1
  • Zehava Graber1
  • Ricardo Lopez2
  • Celeste M Defillo-Lopez3
  1. 1Medicine, New York Institute of Technology (NYIT) College of Osteopathic Medicine, Old Westbury, USA
  2. 2Critical Care Medicine, Internal Medicine, and Pulmonary Diseases, Icahn School of Medicine at Mount Sinai, Queens Hospital Center/HHC, New York, USA
  3. 3Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center/HHC, New York, USA
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Abstract

Kaposi sarcoma (KS) is an angioproliferative neoplasm associated with human herpesvirus-8 (HHV-8) and remains one of the most prevalent acquired immunodeficiency syndrome (AIDS)-defining malignancies globally. Although its incidence has decreased with the widespread implementation of antiretroviral therapy (ART), KS continues to pose therapeutic challenges, particularly in patients with advanced or recurrent disease. We present the case of a 31-year-old man with human immunodeficiency virus (HIV) on ART who developed recurrent KS with cutaneous and pulmonary involvement. The patient had multiple complaints of progressive bilateral thigh and groin swelling and was treated with pegylated liposomal doxorubicin (PLD). This case underscores the aggressive nature of AIDS-related KS in young patients despite ART and first-line chemotherapy, highlighting the critical importance of early recognition, individualized management, and adherence to treatment protocols to optimize patient outcomes.

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Cite

BibTeXRIS
BibTeX
@article{levitt2026unveiling,
  title = {{Unveiling Kaposi Sarcoma: A Case Report on the Clinical Journey in an HIV-Infected Patient}},
  author = {Tzipora Levitt and Amy Chen and Jonathan Shadan and Zehava Graber and Ricardo Lopez and Celeste M Defillo-Lopez},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117473},
  url = {https://doi.org/10.7759/cureus.117473},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Unveiling Kaposi Sarcoma: A Case Report on the Clinical Journey in an HIV-Infected Patient
AU  - Tzipora Levitt
AU  - Amy Chen
AU  - Jonathan Shadan
AU  - Zehava Graber
AU  - Ricardo Lopez
AU  - Celeste M Defillo-Lopez
PY  - 2026
DA  - 2026/10/05
JO  - Cureus
DO  - 10.7759/cureus.117473
UR  - https://doi.org/10.7759/cureus.117473
AB  - Kaposi sarcoma (KS) is an angioproliferative neoplasm associated with human herpesvirus-8 (HHV-8) and remains one of the most prevalent acquired immunodeficiency syndrome (AIDS)-defining malignancies globally. Although its incidence has decreased with the widespread implementation of antiretroviral therapy (ART), KS continues to pose therapeutic challenges, particularly in patients with advanced or recurrent disease. We present the case of a 31-year-old man with human immunodeficiency virus (HIV) on ART who developed recurrent KS with cutaneous and pulmonary involvement. The patient had multiple complaints of progressive bilateral thigh and groin swelling and was treated with pegylated liposomal doxorubicin (PLD). This case underscores the aggressive nature of AIDS-related KS in young patients despite ART and first-line chemotherapy, highlighting the critical importance of early recognition, individualized management, and adherence to treatment protocols to optimize patient outcomes.
SN  - 2168-8184
ER  -