Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds
6 affiliations
- 1Academy of Military Medical Sciences, Beijing, China
- 2CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
- 3Academy of Military Medical Sciences, Beijing, China. [email protected]
- 4CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. [email protected]
- 5Academy of Military Medical Sciences, Beijing, China. [email protected]
- 6Academy of Military Medical Sciences, Beijing, China. [email protected]
Abstract
Drug-resistant bacterium-infected wounds pose a serious clinical challenge, underscoring the need for therapeutic materials that respond to dynamic healing stages. Herein, we report a sequential multimodal platform embedding a self-adaptive IrPtCu nanozyme into a madecassoside-enriched hyaluronic acid hydrogel (HIPCM) for rapid bacterial eradication and accelerated wound healing. Leveraging trimetallic synergy and pH-adaptive reactive oxygen species (ROS) regulation, IrPtCu nanozyme exhibits strong oxidase, peroxidase, glutathione oxidase, and glutathione peroxidase-like activities, enabling efficient ROS generation and potent antibacterial performance. After disinfection, it switches to ROS scavenging through superoxide dismutase and catalase-like cascades, alleviating oxidative stress and cooperating with madecassoside to promote tissue repair. In a methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse model, HIPCM demonstrates strong antibacterial efficacy, promotes M2 macrophage polarization and angiogenesis, and accelerates high-quality repair. Preclinical studies in Bama mini-pigs further confirm improved collagen deposition, hair follicle regeneration, and functional restoration. This work offers a comprehensive strategy integrating adaptive nanozymes and natural herbal medicines for treating drug-resistant wounds.
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BibTeX
@article{zhang2026selfadaptive,
title = {{Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds}},
author = {Xiaoyong Zhang and Hang Yu and Kai Zhu and Yao Xiao and Yuxuan Gong and Dandan Che and Wanyi Chen and Guoxing You and Xiyun Yan and Quan Wang and Kelong Fan and Hong Zhou and Gan Chen},
journal = {Nature Communications},
year = {2026},
month = may,
doi = {10.1038/s41467-026-73672-2},
url = {https://doi.org/10.1038/s41467-026-73672-2},
note = {CC BY},
}
RIS
TY - JOUR
TI - Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds
AU - Xiaoyong Zhang
AU - Hang Yu
AU - Kai Zhu
AU - Yao Xiao
AU - Yuxuan Gong
AU - Dandan Che
AU - Wanyi Chen
AU - Guoxing You
AU - Xiyun Yan
AU - Quan Wang
AU - Kelong Fan
AU - Hong Zhou
AU - Gan Chen
PY - 2026
DA - 2026/05/28
JO - Nature Communications
DO - 10.1038/s41467-026-73672-2
UR - https://doi.org/10.1038/s41467-026-73672-2
AB - Drug-resistant bacterium-infected wounds pose a serious clinical challenge, underscoring the need for therapeutic materials that respond to dynamic healing stages. Herein, we report a sequential multimodal platform embedding a self-adaptive IrPtCu nanozyme into a madecassoside-enriched hyaluronic acid hydrogel (HIPCM) for rapid bacterial eradication and accelerated wound healing. Leveraging trimetallic synergy and pH-adaptive reactive oxygen species (ROS) regulation, IrPtCu nanozyme exhibits strong oxidase, peroxidase, glutathione oxidase, and glutathione peroxidase-like activities, enabling efficient ROS generation and potent antibacterial performance. After disinfection, it switches to ROS scavenging through superoxide dismutase and catalase-like cascades, alleviating oxidative stress and cooperating with madecassoside to promote tissue repair. In a methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse model, HIPCM demonstrates strong antibacterial efficacy, promotes M2 macrophage polarization and angiogenesis, and accelerates high-quality repair. Preclinical studies in Bama mini-pigs further confirm improved collagen deposition, hair follicle regeneration, and functional restoration. This work offers a comprehensive strategy integrating adaptive nanozymes and natural herbal medicines for treating drug-resistant wounds.
SN - 2041-1723
ER -