The effect of polytetrafluoroethylene on different ocular tissues
4 affiliations
- 1Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa
- 2Department of Ophthalmology, Samsun University Faculty of Medicine
- 3Department of Ophthalmology, Care Vision
- 4Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa
Abstract
Background This study aimed to investigate the effects of polytetrafluoroethylene (PTFE) on ocular tissues (sclera, anterior chamber, and vitreous) and to evaluate the safety of PTFE in surgical interventions involving these tissues. Materials and methods After autoclave sterilization, 16 PTFE pieces (6 × 6 mm) were implanted into the anterior chamber and vitreous cavity. Eight PTFE pieces were implanted through the limbus into the right eyes of eight rabbits by creating a corneoscleral tunnel with a 20-G microvitreoretinal (MVR) blade, ensuring that one edge of the implant contacted the anterior chamber of the eye. The remaining eight PTFE pieces were implanted into the vitreous cavity of the right eye of another eight rabbits via a sclerotomy performed 2 mm posterolateral to the limbus using a 20-G MVR blade. The sclerotomy site and conjunctiva were closed using 8 − 0 Vicryl sutures. The left eye of each rabbit was used as a control. Results Conjunctival hyperemia was observed at the incision sites on postoperative day 1 and at week 1. No other inflammatory signs were detected in the anterior segment during the follow-up. Indirect ophthalmoscopy fundus examination revealed no inflammatory or infectious findings. Histopathological examination revealed no differences regard to necrosis or inflammation between the ocular tissues of PTFE-implanted and control eyes. Conclusion No inflammatory or toxic effects were observed one month after PTFE implantation into the ocular tissues. In summary, PTFE appears to be relatively harmless to ocular tissues in surgical practices at least in short term.
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BibTeX
@article{dogan2026effect,
title = {{The effect of polytetrafluoroethylene on different ocular tissues}},
author = {Cezmi Doğan and Oğuzhan Kılıçarslan and Hüseyin Yetik and Burak Mergen and Fatma Burcu Özdemir and Övgü Aydın},
journal = {BMC Ophthalmology},
year = {2026},
month = jul,
doi = {10.1186/s12886-026-05154-4},
url = {https://doi.org/10.1186/s12886-026-05154-4},
note = {CC BY},
}
RIS
TY - JOUR
TI - The effect of polytetrafluoroethylene on different ocular tissues
AU - Cezmi Doğan
AU - Oğuzhan Kılıçarslan
AU - Hüseyin Yetik
AU - Burak Mergen
AU - Fatma Burcu Özdemir
AU - Övgü Aydın
PY - 2026
DA - 2026/07/01
JO - BMC Ophthalmology
DO - 10.1186/s12886-026-05154-4
UR - https://doi.org/10.1186/s12886-026-05154-4
AB - Background This study aimed to investigate the effects of polytetrafluoroethylene (PTFE) on ocular tissues (sclera, anterior chamber, and vitreous) and to evaluate the safety of PTFE in surgical interventions involving these tissues. Materials and methods After autoclave sterilization, 16 PTFE pieces (6 × 6 mm) were implanted into the anterior chamber and vitreous cavity. Eight PTFE pieces were implanted through the limbus into the right eyes of eight rabbits by creating a corneoscleral tunnel with a 20-G microvitreoretinal (MVR) blade, ensuring that one edge of the implant contacted the anterior chamber of the eye. The remaining eight PTFE pieces were implanted into the vitreous cavity of the right eye of another eight rabbits via a sclerotomy performed 2 mm posterolateral to the limbus using a 20-G MVR blade. The sclerotomy site and conjunctiva were closed using 8 − 0 Vicryl sutures. The left eye of each rabbit was used as a control. Results Conjunctival hyperemia was observed at the incision sites on postoperative day 1 and at week 1. No other inflammatory signs were detected in the anterior segment during the follow-up. Indirect ophthalmoscopy fundus examination revealed no inflammatory or infectious findings. Histopathological examination revealed no differences regard to necrosis or inflammation between the ocular tissues of PTFE-implanted and control eyes. Conclusion No inflammatory or toxic effects were observed one month after PTFE implantation into the ocular tissues. In summary, PTFE appears to be relatively harmless to ocular tissues in surgical practices at least in short term.
SN - 1471-2415
ER -