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Peer-reviewedCC BY-NCRSC advances

Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles.

  • Hong-Hai Zhang1
  • Wellington Leite2
  • Sai Venkatesh Pingali2
  • Brandon Nusser1
  • Volker S Urban2
  • Hugh O'Neill2
  1. 1Center for Nanophase Materials Sciences, Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA [email protected].
  2. 2Neutron Scattering Division, Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA.
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Abstract

Deuterated ALC-0315 was synthesized via two steps from three deuterated precursors. A hydrogen-deuterium (H/D) exchange protocol using a Pt/C catalyst was developed for the key precursor, 1-amino-butanol-d8. SANS study reveals that deuteration significantly increases the contrast match point (CMP) of ALC-0315, allowing for contrast-variation small angle neutron scattering measurements to selectively highlight internal LNP core-shell structure.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026synthesis,
  title = {{Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles.}},
  author = {Hong-Hai Zhang and Wellington Leite and Sai Venkatesh Pingali and Brandon Nusser and Volker S Urban and Hugh O'Neill},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra04368b},
  url = {https://europepmc.org/article/MED/42953127},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles.
AU  - Hong-Hai Zhang
AU  - Wellington Leite
AU  - Sai Venkatesh Pingali
AU  - Brandon Nusser
AU  - Volker S Urban
AU  - Hugh O'Neill
PY  - 2026
DA  - 2026/10/28
JO  - RSC advances
DO  - 10.1039/d6ra04368b
UR  - https://europepmc.org/article/MED/42953127
AB  - Deuterated ALC-0315 was synthesized via two steps from three deuterated precursors. A hydrogen-deuterium (H/D) exchange protocol using a Pt/C catalyst was developed for the key precursor, 1-amino-butanol-d8. SANS study reveals that deuteration significantly increases the contrast match point (CMP) of ALC-0315, allowing for contrast-variation small angle neutron scattering measurements to selectively highlight internal LNP core-shell structure.
SN  - 2046-2069
ER  -