Skip to content
DraconiticResearch
Search Sources API
194,161 studies31 sourcesUpdated 28 min ago
Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Toward an Appropriate Classification of Adult-Onset Diabetes Mellitus: A Descriptive Study in Primary Care

  • Pilar Vich-Pérez1,2
  • Belén Taulero-Escalera3
  • Paula Regueiro-Toribio2,4
  • Irene Moratinos-Recuenco1
  • Javier Hernández-Jiménez1
  • Laura Villanova-Cuadra5
  • Ignacio Sevilla-Machuca1
  • Julia Timoner-García5
  • Mario Martínez-Grandmontagne6
  • Tania Abós-Pueyo7
  • Cristina Álvarez-Hernández-Cañizares8
  • Germán Reviriego-Jaén9
5 more authors
  • Alberto Serrano-López-Hazas10
  • Inés Gala-Molina11
  • Mar Sanz-Pascual12
  • Miguel Angel Salinero-Fort2,13,14,15
  • on behalf of the LADA-PC Consortium
15 affiliations
  1. 1Los Alpes Health Center, 28022 Madrid, Spain
  2. 2Foundation for Biosanitary Research and Innovation in Primary Care, The Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain
  3. 3Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Gregorio Marañón Institute of Health Research(IiSGM), Biomedical Research Centre for Mental Health (CIBERSAM), Carlos III Health Institute (ISCIII), School of Medicine, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
  4. 4Mar Báltico Health Center, 28033 Madrid, Spain
  5. 5Doctor Cirajas Health Center, 28017 Madrid, Spain
  6. 6Sanchinarro Health Center, 28050 Madrid, Spain
  7. 7Estrecho de Corea Health Center, 28027 Madrid, Spain
  8. 8Canillejas Health Center, 28022 Madrid, Spain
  9. 9Barajas Health Center, 28042 Madrid, Spain
  10. 10García Noblejas Health Center, 28037 Madrid, Spain
  11. 11Benita de Ávila Health Center, 28043 Madrid, Spain
  12. 12Aquitania Health Center, 28032 Madrid, Spain
  13. 13Alfonso X El Sabio University, 28691 Madrid, Spain
  14. 14Research Network on Chronicity, Primary Care and Health Promotion—RICAPPS—(RICORS), 28029 Madrid, Spain
  15. 15General Directorate of Research and Documentation, Department of Health, 28013 Madrid, Spain
Open at sourceDOICite

Abstract

Background: Type 2 diabetes mellitus (T2DM) is the most common form of diabetes in adults, although autoimmune reactions against pancreatic islets may also occur, leading to early insulin dependence and specific clinical features. The misclassification of autoimmune diabetes (AD) in adults has clinical implications in primary care (PC), where autoantibody testing is limited. The aim of this study was to estimate the prevalence of AD in adults at the time of diagnosis and to characterize its clinical, metabolic and lifestyle profile in comparison with that of T2DM patients. Methods: A cross-sectional study was conducted at 12 PC centers in Madrid (Spain). A total of 1006 adults aged 30 years or older who had been diagnosed with diabetes within the previous four years were included. Autoantibodies against pancreatic islets (anti-GAD65 and anti-IA-2) were analyzed in a centralized laboratory. Clinical interviews, physical examinations and reviews of electronic medical records were carried out. Results: The prevalence of AD was 7.56%. Patients with AD were younger and leaner and had more hyperglycemic symptoms and higher HbA1c levels. They had higher HDL cholesterol levels, lower triglyceride levels and more favorable cardiometabolic indices than patients with T2DM did. Patients with AD with LADA criteria differed from those with early insulin dependence. Conclusions: Autoimmune diabetes is a relatively common form of diabetes in adults and presents a clinical and metabolic profile that differs from that of T2DM. Improved recognition and targeted screening in primary care may facilitate accurate diagnosis and more appropriate therapeutic decision-making.

Related

  1. Association between diabetes mellitus and hearing impairment in the adult Canadian population: data from the Canadian longitudinal study on aging
    Xuan Nhi Nguyen, Adrian Fuente
    BMC Public HealthPeer-reviewedCC BY-NC-ND 4.0NeuroscienceCrossref
  2. Types 1 diabetes mellitus and Graves' disease in Sanjad-Sakati syndrome: a case report in Saudi Arabia.
    Ghada Almasri, Alaa Ahmed Almubayedh, Maryam Zaitoun +2
    Frontiers in endocrinologyPeer-reviewedCC BYFull textGenetics & genomicsEurope PMCCrossref
  3. Inflammatory biomarkers and immune dysregulation in gestational diabetes mellitus: emerging mechanisms and therapeutic prospects
    Qian Zhang, Yang Shu, Yanan Gao
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0ImmunologyFrontiersCrossref
  4. Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway
    J. Zhu, Z. Pan, S. Wang +6
    bioRxivPreprintCC BYFull textCell biologybioRxiv
  5. DIRECTION-AWARE INTEGRATED BIOINFORMATICS ANALYSIS REVEALS CONCORDANT AND DISCORDANT MOLECULAR SIGNATURES LINKING TYPE 2 DIABETES MELLITUS AND POLYCYSTIC OVARY SYNDROME
    s. O. Abdulsalam, D. A. Akanbi, T. E. Aloba +2
    bioRxivPreprintCC BY-NCFull textBioinformatics & computational biologybioRxiv

Cite

BibTeXRIS
BibTeX
@article{vichperez2026toward,
  title = {{Toward an Appropriate Classification of Adult-Onset Diabetes Mellitus: A Descriptive Study in Primary Care}},
  author = {Pilar Vich-Pérez and Belén Taulero-Escalera and Paula Regueiro-Toribio and Irene Moratinos-Recuenco and Javier Hernández-Jiménez and Laura Villanova-Cuadra and Ignacio Sevilla-Machuca and Julia Timoner-García and Mario Martínez-Grandmontagne and Tania Abós-Pueyo and Cristina Álvarez-Hernández-Cañizares and Germán Reviriego-Jaén and Alberto Serrano-López-Hazas and Inés Gala-Molina and Mar Sanz-Pascual and Miguel Angel Salinero-Fort and on behalf of the LADA-PC Consortium},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15218317},
  url = {https://www.mdpi.com/2077-0383/15/21/8317},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Toward an Appropriate Classification of Adult-Onset Diabetes Mellitus: A Descriptive Study in Primary Care
AU  - Pilar Vich-Pérez
AU  - Belén Taulero-Escalera
AU  - Paula Regueiro-Toribio
AU  - Irene Moratinos-Recuenco
AU  - Javier Hernández-Jiménez
AU  - Laura Villanova-Cuadra
AU  - Ignacio Sevilla-Machuca
AU  - Julia Timoner-García
AU  - Mario Martínez-Grandmontagne
AU  - Tania Abós-Pueyo
AU  - Cristina Álvarez-Hernández-Cañizares
AU  - Germán Reviriego-Jaén
AU  - Alberto Serrano-López-Hazas
AU  - Inés Gala-Molina
AU  - Mar Sanz-Pascual
AU  - Miguel Angel Salinero-Fort
AU  - on behalf of the LADA-PC Consortium
PY  - 2026
DA  - 2026/10/26
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218317
UR  - https://www.mdpi.com/2077-0383/15/21/8317
AB  - Background: Type 2 diabetes mellitus (T2DM) is the most common form of diabetes in adults, although autoimmune reactions against pancreatic islets may also occur, leading to early insulin dependence and specific clinical features. The misclassification of autoimmune diabetes (AD) in adults has clinical implications in primary care (PC), where autoantibody testing is limited. The aim of this study was to estimate the prevalence of AD in adults at the time of diagnosis and to characterize its clinical, metabolic and lifestyle profile in comparison with that of T2DM patients. Methods: A cross-sectional study was conducted at 12 PC centers in Madrid (Spain). A total of 1006 adults aged 30 years or older who had been diagnosed with diabetes within the previous four years were included. Autoantibodies against pancreatic islets (anti-GAD65 and anti-IA-2) were analyzed in a centralized laboratory. Clinical interviews, physical examinations and reviews of electronic medical records were carried out. Results: The prevalence of AD was 7.56%. Patients with AD were younger and leaner and had more hyperglycemic symptoms and higher HbA1c levels. They had higher HDL cholesterol levels, lower triglyceride levels and more favorable cardiometabolic indices than patients with T2DM did. Patients with AD with LADA criteria differed from those with early insulin dependence. Conclusions: Autoimmune diabetes is a relatively common form of diabetes in adults and presents a clinical and metabolic profile that differs from that of T2DM. Improved recognition and targeted screening in primary care may facilitate accurate diagnosis and more appropriate therapeutic decision-making.
SN  - 2077-0383
ER  -