Naringenin-Mn self-fueling dual-dynamic hydrogel with cascade catalysis and immunomodulation properties for repairing MRSA-infected diabetic wounds.
- 1Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
- 2Thyroid and Breast Surgery, The Fourth People's Hospital of Jinan, Jinan, China.
Abstract
Chronic infectious wounds in diabetic patients remain a significant clinical challenge due to persistent inflammation, oxidative stress, and bacterial resistance issues. This problem is particularly acute in the area of postoperative surgical incisions, where impaired healing can lead to serious complications. This study aimed to develop a self-healing cascade-catalyzed hydrogel, CS-PBA/ODex@NRGe-Mn (CPONM), featuring boronate ester bond and Schiff base bond. This hydrogel exhibits a dual dynamic network structure and incorporates naringenin-Mn nanoparticles (NM NPs) with SOD/POD-like activity. The hydrogel was synthesized by mixing CS-PBA solution with ODex solution containing NM NPs. CPONM exhibits high porosity, swelling capacity, adhesion strength (13.43 kPa), and pH-responsive release properties. In vitro studies demonstrated that CPONM effectively inhibited the growth of Escherichia coli (E.coli, 93.15%) and methicillin-resistant Staphylococcus aureus (MRSA, 94.74%), disrupted bacterial biofilms by up to 92%, and reduced iNOS and IL-6 expression in macrophages. In a diabetic mouse wound model infected with MRSA, CPONM accelerated wound healing (reaching 97.47% by day 18), reduced bacterial infection risk, inhibited NF-κB, and activated Nrf2. Histopathological staining revealed the hydrogel's ability to promote wound epithelialization, collagen deposition, and vascular growth (VEGF, α-SMA). Quantitative measurements of reactive oxygen species (ROS) in wound tissue on Day 3 showed that O2·- decreased by 0.32 μmol/g, while ·OH increased by 18.7%, directly demonstrating the "self-fueling" cascade reaction of SOD and POD. Therefore, CPONM represents a promising approach for treating infected postoperative wounds in diabetic patients.
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BibTeX
@article{qi2026naringeninmn,
title = {{Naringenin-Mn self-fueling dual-dynamic hydrogel with cascade catalysis and immunomodulation properties for repairing MRSA-infected diabetic wounds.}},
author = {Ming Qi and Tong Li and Gengyu Chen and Gangpu Wang and Guofeng Dai and Jing Xue and Chi Zhang},
journal = {Materials today. Bio},
year = {2026},
month = oct,
doi = {10.1016/j.mtbio.2026.103787},
url = {https://europepmc.org/article/MED/42997137},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Naringenin-Mn self-fueling dual-dynamic hydrogel with cascade catalysis and immunomodulation properties for repairing MRSA-infected diabetic wounds.
AU - Ming Qi
AU - Tong Li
AU - Gengyu Chen
AU - Gangpu Wang
AU - Guofeng Dai
AU - Jing Xue
AU - Chi Zhang
PY - 2026
DA - 2026/10/26
JO - Materials today. Bio
DO - 10.1016/j.mtbio.2026.103787
UR - https://europepmc.org/article/MED/42997137
AB - Chronic infectious wounds in diabetic patients remain a significant clinical challenge due to persistent inflammation, oxidative stress, and bacterial resistance issues. This problem is particularly acute in the area of postoperative surgical incisions, where impaired healing can lead to serious complications. This study aimed to develop a self-healing cascade-catalyzed hydrogel, CS-PBA/ODex@NRGe-Mn (CPONM), featuring boronate ester bond and Schiff base bond. This hydrogel exhibits a dual dynamic network structure and incorporates naringenin-Mn nanoparticles (NM NPs) with SOD/POD-like activity. The hydrogel was synthesized by mixing CS-PBA solution with ODex solution containing NM NPs. CPONM exhibits high porosity, swelling capacity, adhesion strength (13.43 kPa), and pH-responsive release properties. In vitro studies demonstrated that CPONM effectively inhibited the growth of Escherichia coli (E.coli, 93.15%) and methicillin-resistant Staphylococcus aureus (MRSA, 94.74%), disrupted bacterial biofilms by up to 92%, and reduced iNOS and IL-6 expression in macrophages. In a diabetic mouse wound model infected with MRSA, CPONM accelerated wound healing (reaching 97.47% by day 18), reduced bacterial infection risk, inhibited NF-κB, and activated Nrf2. Histopathological staining revealed the hydrogel's ability to promote wound epithelialization, collagen deposition, and vascular growth (VEGF, α-SMA). Quantitative measurements of reactive oxygen species (ROS) in wound tissue on Day 3 showed that O2·- decreased by 0.32 μmol/g, while ·OH increased by 18.7%, directly demonstrating the "self-fueling" cascade reaction of SOD and POD. Therefore, CPONM represents a promising approach for treating infected postoperative wounds in diabetic patients.
SN - 2590-0064
ER -