Rome V global epidemiology and validation survey: prevalence of disorders of gut–brain interaction and comparison with the Rome IV global epidemiology study
Abstract
BACKGROUND: The recently published Rome V adult diagnostic criteria facilitated an updated epidemiological survey of disorders of gut-brain interaction (DGBI). OBJECTIVE: We aimed to describe the global epidemiology of DGBI using the Rome V criteria and compare it with the Rome IV Rome Foundation Global Epidemiology Study. METHODS: A population-based Internet survey of 28,771 adults was conducted in 15 countries using the Rome V diagnostic questionnaire. DGBI prevalence was determined and compared with the Rome IV data. Multivariable logistic regression models were used to examine associations of demographic factors to Rome V DGBI status in the global population and to assess potentially associated clinical factors. RESULTS: The surveys yielded similar results. The prevalence of at least one DGBI using the Rome V criteria was 40.9%, compared with 40.5% for Rome IV. In both, the prevalence was higher among females and decreased with increasing age. In the Rome V sample (25 DGBI), the most prevalent oesophageal disorder was functional dysphagia at 4.1%, the most prevalent gastroduodenal disorder was functional dyspepsia at 8.1%, unclassified bowel disorder was the most prevalent bowel disorder (9.6%), followed by chronic constipation (8.9%) and IBS (8.5%) and proctalgia fugax was the most prevalent anorectal disorder (7.3%). The prevalence rates for two new DGBI were 5.1% for abdominal migraine and 1.4% for inability to belch syndrome. CONCLUSION: The Rome V global prevalence of DGBI is consistent with Rome IV. This bolsters confidence in the validity of prevalence rates for DGBI and reaffirms their high global burden.
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BibTeX
@article{sperber2026rome,
title = {{Rome V global epidemiology and validation survey: prevalence of disorders of gut–brain interaction and comparison with the Rome IV global epidemiology study}},
author = {Ami Sperber and Johann Hreinsson and Magnus Simrén and Douglas Drossman and Viola Andresen and Serhat Bor and Dan Dumitrascu and Xiucai Fang and Guijun Fei and Luis Bustos Fernandez and Carlos Francesconi and Shin Fukudo and Sang Kil Lee and Chloé Melchior and Agata Mulak and Anne Peery and David Rodrigues and Javier Santos and Max Schmulson and Dipesh Vasant and Jan Tack and Tiffany Taft and Olafur Palsson},
journal = {Gut},
year = {2026},
month = aug,
doi = {10.1136/gutjnl-2026-339666},
url = {https://normandie-univ.hal.science/hal-05771332v1},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Rome V global epidemiology and validation survey: prevalence of disorders of gut–brain interaction and comparison with the Rome IV global epidemiology study
AU - Ami Sperber
AU - Johann Hreinsson
AU - Magnus Simrén
AU - Douglas Drossman
AU - Viola Andresen
AU - Serhat Bor
AU - Dan Dumitrascu
AU - Xiucai Fang
AU - Guijun Fei
AU - Luis Bustos Fernandez
AU - Carlos Francesconi
AU - Shin Fukudo
AU - Sang Kil Lee
AU - Chloé Melchior
AU - Agata Mulak
AU - Anne Peery
AU - David Rodrigues
AU - Javier Santos
AU - Max Schmulson
AU - Dipesh Vasant
AU - Jan Tack
AU - Tiffany Taft
AU - Olafur Palsson
PY - 2026
DA - 2026/08/18
JO - Gut
DO - 10.1136/gutjnl-2026-339666
UR - https://normandie-univ.hal.science/hal-05771332v1
AB - BACKGROUND: The recently published Rome V adult diagnostic criteria facilitated an updated epidemiological survey of disorders of gut-brain interaction (DGBI). OBJECTIVE: We aimed to describe the global epidemiology of DGBI using the Rome V criteria and compare it with the Rome IV Rome Foundation Global Epidemiology Study. METHODS: A population-based Internet survey of 28,771 adults was conducted in 15 countries using the Rome V diagnostic questionnaire. DGBI prevalence was determined and compared with the Rome IV data. Multivariable logistic regression models were used to examine associations of demographic factors to Rome V DGBI status in the global population and to assess potentially associated clinical factors. RESULTS: The surveys yielded similar results. The prevalence of at least one DGBI using the Rome V criteria was 40.9%, compared with 40.5% for Rome IV. In both, the prevalence was higher among females and decreased with increasing age. In the Rome V sample (25 DGBI), the most prevalent oesophageal disorder was functional dysphagia at 4.1%, the most prevalent gastroduodenal disorder was functional dyspepsia at 8.1%, unclassified bowel disorder was the most prevalent bowel disorder (9.6%), followed by chronic constipation (8.9%) and IBS (8.5%) and proctalgia fugax was the most prevalent anorectal disorder (7.3%). The prevalence rates for two new DGBI were 5.1% for abdominal migraine and 1.4% for inability to belch syndrome. CONCLUSION: The Rome V global prevalence of DGBI is consistent with Rome IV. This bolsters confidence in the validity of prevalence rates for DGBI and reaffirms their high global burden.
SN - 0017-5749
SN - 1468-3288
ER -