Skip to content
DraconiticResearch
Search Sources API
186,123 studies31 sourcesUpdated 1 min ago
Peer-reviewedCC BY 4.0Médecine/Sciences

Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac®

  • Marine O Faucher
  • Karine Barral
  • Bruno Coutard
Open at sourcePDFDOICite

Abstract

Drug repurposing represents a strategic approach aimed at accelerating the development of treatments against viral infections. This review presents three repurposing strategies, illustrated with therapeutic compounds notably fluoxetine (Prozac ® ), a selective serotonin reuptake inhibitor antidepressant that also exhibits several antiviral mechanisms of action. The examples discussed in this review highlight both the potential and the limitations of drug repurposing, particularly in a “plug-and-play” approach.

Related

  1. Repurposing the phospholipase A2 inhibitor, darapladib, to combat multidrug-resistant fungal pathogens, including Candida auris
    Yehia Elgammal, Ehab A Salama, Nour M Alkashef +2
    PLOS OnePeer-reviewedCC BYFull textMicrobiologyPharmacology & toxicologyPLOSEurope PMC
  2. Point-of-care testing in the diagnosis of infectious diseases
    Quan Fang, Yuyan Lin, Guiqi Hu +5
    Frontiers in MicrobiologyPeer-reviewedCC BY 4.0Full textMicrobiologyCrossrefEurope PMC
  3. Drivers of the likelihood of evolutionary rescue in response to novel infectious diseases.
    Laurinne J Balstad, Marissa L Baskett
    Proceedings of the National Academy of Sciences of the United States of AmericaPeer-reviewedCC BYFull textGenetics & genomicsEurope PMC
  4. Remote Body Temperature Monitoring in Infectious Diseases: Pilot Studies in Different Artiodactyla Models.
    Timm Konold, Sarah Wallworth, Christina Roccia +7
    BiologyPeer-reviewedCC BYFull textZoology & animal behaviourEurope PMC
  5. Global sensitivity analysis for stochastic models of infectious diseases: Re-emergence of yellow fever virus in the Americas as a case study
    Nate Kornetzke, Helen J. Wearing
    PLOS Computational BiologyPeer-reviewedCC BY 4.0Full textEcologyZoology & animal behaviourPLOS

Cite

BibTeXRIS
BibTeX
@article{faucher2026drug,
  title = {{Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac®}},
  author = {Marine O Faucher and Karine Barral and Bruno Coutard},
  journal = {Médecine/Sciences},
  year = {2026},
  month = sep,
  doi = {10.1051/medsci/2026123},
  url = {https://hal.science/hal-05749070v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Drug repurposing to combat viral infectious diseases: principles and illustration with Prozac®
AU  - Marine O Faucher
AU  - Karine Barral
AU  - Bruno Coutard
PY  - 2026
DA  - 2026/09/14
JO  - Médecine/Sciences
DO  - 10.1051/medsci/2026123
UR  - https://hal.science/hal-05749070v1
AB  - Drug repurposing represents a strategic approach aimed at accelerating the development of treatments against viral infections. This review presents three repurposing strategies, illustrated with therapeutic compounds notably fluoxetine (Prozac ® ), a selective serotonin reuptake inhibitor antidepressant that also exhibits several antiviral mechanisms of action. The examples discussed in this review highlight both the potential and the limitations of drug repurposing, particularly in a “plug-and-play” approach.
SN  - 0767-0974
SN  - 1958-5381
ER  -