Atypical Subacute Thyroiditis without Thyroid Dysfunction: A Report of Two Cases

Abstract

Subacute thyroiditis (SAT) is a painful inflammation of the thyroid that causes transient thyrotoxicosis, followed by hypothyroidism and an eventual recovery. We report two atypical cases of SAT that presented with anterior neck pain, tender thyroid nodules, elevated inflammatory markers, and characteristic ultrasound findings, all suggestive of SAT, but who remained euthyroid throughout their courses. The serum thyroglobulin level increased in one case. These cases demonstrate rare euthyroid presentations of SAT despite not meeting the current diagnostic criteria for SAT established by the Japan Thyroid Association, and underscore that normal thyroid function tests do not exclude this diagnosis.

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BibTeX RIS

BibTeX

@article{nagayama2026atypical,
  title = {{Atypical Subacute Thyroiditis without Thyroid Dysfunction: A Report of Two Cases}},
  author = {Yuji Nagayama and Seigo Tachibana and Takashi Fukuda and Hiroyuki Yamashita},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.7012-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_7012-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Atypical Subacute Thyroiditis without Thyroid Dysfunction: A Report of Two Cases
AU  - Yuji Nagayama
AU  - Seigo Tachibana
AU  - Takashi Fukuda
AU  - Hiroyuki Yamashita
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7012-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_7012-25/_article
AB  - Subacute thyroiditis (SAT) is a painful inflammation of the thyroid that causes transient thyrotoxicosis, followed by hypothyroidism and an eventual recovery. We report two atypical cases of SAT that presented with anterior neck pain, tender thyroid nodules, elevated inflammatory markers, and characteristic ultrasound findings, all suggestive of SAT, but who remained euthyroid throughout their courses. The serum thyroglobulin level increased in one case. These cases demonstrate rare euthyroid presentations of SAT despite not meeting the current diagnostic criteria for SAT established by the Japan Thyroid Association, and underscore that normal thyroid function tests do not exclude this diagnosis.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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