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Peer-reviewedCC BY 4.0Frontiers in Endocrinology

Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss

  • Zhisong Yan1
  • Weilin Chen1
  • Xiaoyang Cao1
  • Xiaodong Chen1
  1. 1Department of Otolaryngology, Tongzhou Branch of Nantong People’s Hospital (Nantong Tongzhou People’s Hospital)
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Abstract

Objective: To investigate the association between the apolipoprotein B to apolipoprotein A (ApoB/ApoA) ratio and sudden sensorineural hearing loss (SSNHL) risk in Nantong, China.

Methods: This cross-sectional study included 1211 participants (674 with normal hearing, 537 with SSNHL). Baseline demographics, comorbidities, and biochemical indicators were compared. Multivariable logistic regression evaluated the independent association between the ApoB/ApoA ratio and SSNHL risk. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were applied for sensitivity analysis. Stratified and dose-response analyses were also conducted.

Results: The groups differed significantly in age, sex, hypertension, BMI, and various metabolic markers (all P < 0.05). In the fully adjusted model, an elevated ApoB/ApoA ratio was significantly associated with increased SSNHL risk (OR = 9.34, 95% CI: 3.93-22.21). This positive association remained robust after PSM (OR = 8.79, 95% CI: 3.26-23.66). IPTW analysis showed the high-ratio group (0.78-1.34) had a higher SSNHL risk than the low-ratio group (0.13-0.58) (OR = 2.28, 95% CI: 1.79-2.90). Dose-response analysis indicated a significant linear positive correlation between the ratio and SSNHL prevalence, both before and after PSM. Stratified analyses demonstrated this association remained consistent across age, sex, hypertension, and diabetes subgroups (all P for interaction > 0.05).

Conclusion: A high ApoB/ApoA ratio has a significant linear positive association with increased SSNHL risk. It serves as an independent clinical biomarker for SSNHL risk assessment, providing a basis for metabolic management.

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Cite

BibTeXRIS
BibTeX
@article{yan2026elevated,
  title = {{Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss}},
  author = {Zhisong Yan and Weilin Chen and Xiaoyang Cao and Xiaodong Chen},
  journal = {Frontiers in Endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1955992},
  url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1955992/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss
AU  - Zhisong Yan
AU  - Weilin Chen
AU  - Xiaoyang Cao
AU  - Xiaodong Chen
PY  - 2026
DA  - 2026/10/15
JO  - Frontiers in Endocrinology
DO  - 10.3389/fendo.2026.1955992
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2026.1955992/full
AB  - Objective: To investigate the association between the apolipoprotein B to apolipoprotein A (ApoB/ApoA) ratio and sudden sensorineural hearing loss (SSNHL) risk in Nantong, China.  Methods: This cross-sectional study included 1211 participants (674 with normal hearing, 537 with SSNHL). Baseline demographics, comorbidities, and biochemical indicators were compared. Multivariable logistic regression evaluated the independent association between the ApoB/ApoA ratio and SSNHL risk. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were applied for sensitivity analysis. Stratified and dose-response analyses were also conducted.  Results: The groups differed significantly in age, sex, hypertension, BMI, and various metabolic markers (all P < 0.05). In the fully adjusted model, an elevated ApoB/ApoA ratio was significantly associated with increased SSNHL risk (OR = 9.34, 95% CI: 3.93-22.21). This positive association remained robust after PSM (OR = 8.79, 95% CI: 3.26-23.66). IPTW analysis showed the high-ratio group (0.78-1.34) had a higher SSNHL risk than the low-ratio group (0.13-0.58) (OR = 2.28, 95% CI: 1.79-2.90). Dose-response analysis indicated a significant linear positive correlation between the ratio and SSNHL prevalence, both before and after PSM. Stratified analyses demonstrated this association remained consistent across age, sex, hypertension, and diabetes subgroups (all P for interaction > 0.05).  Conclusion: A high ApoB/ApoA ratio has a significant linear positive association with increased SSNHL risk. It serves as an independent clinical biomarker for SSNHL risk assessment, providing a basis for metabolic management.
SN  - 1664-2392
ER  -