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Peer-reviewedCC BY 4.0Annals of Gastroenterological Surgery

Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study

  • Kentaro Goto1
  • Shigeo Hisamori1
  • Kohei Ueno1
  • Hiroyasu Abe2
  • Ryosuke Okamura1
  • Hisahiro Hosogi3
  • Yoshito Yamashita4
  • Dai Manaka5
  • Hiroaki Hata6
  • Tatsuto Nishigori7
  • Sanae Nakajima8
  • Michihiro Yamamoto9
7 more authors
  • Koichi Kinoshita10
  • Shintaro Okumura1
  • Masazumi Sakaguchi1
  • Shigeru Tsunoda1
  • Yu Sakagami11
  • Koya Hida1
  • Kazutaka Obama1
11 affiliations
  1. 1Department of Surgery Kyoto University Kyoto Japan
  2. 2Department of Regulatory Science and Pharmaceutical Informatics, School of Pharmaceutical Sciences Wakayama Medical University Wakayama Japan
  3. 3Department of Surgery Osaka Red Cross Hospital Osaka Japan
  4. 4Department of Gastrointestinal Surgery Japanese Red Cross Wakayama Medical Center Wakayama Japan
  5. 5Department of Surgery Kyoto‐Katsura Hospital Kyoto Japan
  6. 6Department of Surgery National Hospital Organization Kyoto Medical Center Kyoto Japan
  7. 7Department of Gastrointestinal Surgery Kyoto City Hospital Kyoto Japan
  8. 8Department of Surgery Kobe City Medical Center West Hospital Hyogo Japan
  9. 9Department of Gastrointestinal Surgery Tenri Yorozu Hospital Nara Japan
  10. 10Department of Surgery Japan Baptist Hospital Kyoto Japan
  11. 11Occupational Welfare Division, Agency for Health, Safety and Environment Kyoto University Kyoto Japan
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Abstract

Aim: As survival after gastric and esophageal cancer continues to improve, sustained work participation has become an important survivorship outcome. We aimed to evaluate return‐to‐work (RTW) rates 18 months after curative‐intent surgery for gastric and esophageal cancers and to identify clinical and socioeconomic factors associated with delayed or failed RTW.

Methods: This multicenter, longitudinal, prospective cohort study evaluated working‐age Japanese patients undergoing curative‐intent surgery for gastric or esophageal cancer. Working status was assessed preoperatively and at 6, 12, and 18 months postoperatively. The primary outcome was working status at 18 months. Secondary outcomes included time to first RTW, and factors associated with non‐working and delayed RTW. Exploratory analyses evaluated 6‐month patient‐reported outcomes (QLQ‐C30) and postoperative weight loss.

Results: Among 158 eligible patients, 124 (78.5%) were working at 18 months. Older age (≥ 65 years) and pathological stage≥ III were associated with non‐working at 18 months, whereas sedentary work and self‐employment were associated with a lower risk of non‐working. Postoperative appetite loss, financial difficulties (QLQ‐C30), and ≥ 10% body weight loss at 6 months were associated with non‐working status. Median time to first RTW was 30 and 70 days for gastric and esophageal cancers, respectively. Esophageal cancer and advanced stage were consistently associated with delayed RTW, with weaker evidence for associations with female sex and preoperative retirement.

Conclusions: Approximately 80% of patients were working at 18 months after surgery. Postoperative nutritional impairment and symptom burden were associated with long‐term work participation and may help identify patients at risk of not working after surgery.

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Cite

BibTeXRIS
BibTeX
@article{goto2026returntowork,
  title = {{Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study}},
  author = {Kentaro Goto and Shigeo Hisamori and Kohei Ueno and Hiroyasu Abe and Ryosuke Okamura and Hisahiro Hosogi and Yoshito Yamashita and Dai Manaka and Hiroaki Hata and Tatsuto Nishigori and Sanae Nakajima and Michihiro Yamamoto and Koichi Kinoshita and Shintaro Okumura and Masazumi Sakaguchi and Shigeru Tsunoda and Yu Sakagami and Koya Hida and Kazutaka Obama},
  journal = {Annals of Gastroenterological Surgery},
  year = {2026},
  month = jul,
  doi = {10.1002/ags3.70251},
  url = {https://doi.org/10.1002/ags3.70251},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study
AU  - Kentaro Goto
AU  - Shigeo Hisamori
AU  - Kohei Ueno
AU  - Hiroyasu Abe
AU  - Ryosuke Okamura
AU  - Hisahiro Hosogi
AU  - Yoshito Yamashita
AU  - Dai Manaka
AU  - Hiroaki Hata
AU  - Tatsuto Nishigori
AU  - Sanae Nakajima
AU  - Michihiro Yamamoto
AU  - Koichi Kinoshita
AU  - Shintaro Okumura
AU  - Masazumi Sakaguchi
AU  - Shigeru Tsunoda
AU  - Yu Sakagami
AU  - Koya Hida
AU  - Kazutaka Obama
PY  - 2026
DA  - 2026/07/26
JO  - Annals of Gastroenterological Surgery
DO  - 10.1002/ags3.70251
UR  - https://doi.org/10.1002/ags3.70251
AB  - Aim: As survival after gastric and esophageal cancer continues to improve, sustained work participation has become an important survivorship outcome. We aimed to evaluate return‐to‐work (RTW) rates 18 months after curative‐intent surgery for gastric and esophageal cancers and to identify clinical and socioeconomic factors associated with delayed or failed RTW.  Methods: This multicenter, longitudinal, prospective cohort study evaluated working‐age Japanese patients undergoing curative‐intent surgery for gastric or esophageal cancer. Working status was assessed preoperatively and at 6, 12, and 18 months postoperatively. The primary outcome was working status at 18 months. Secondary outcomes included time to first RTW, and factors associated with non‐working and delayed RTW. Exploratory analyses evaluated 6‐month patient‐reported outcomes (QLQ‐C30) and postoperative weight loss.  Results: Among 158 eligible patients, 124 (78.5%) were working at 18 months. Older age (≥ 65 years) and pathological stage≥ III were associated with non‐working at 18 months, whereas sedentary work and self‐employment were associated with a lower risk of non‐working. Postoperative appetite loss, financial difficulties (QLQ‐C30), and ≥ 10% body weight loss at 6 months were associated with non‐working status. Median time to first RTW was 30 and 70 days for gastric and esophageal cancers, respectively. Esophageal cancer and advanced stage were consistently associated with delayed RTW, with weaker evidence for associations with female sex and preoperative retirement.  Conclusions: Approximately 80% of patients were working at 18 months after surgery. Postoperative nutritional impairment and symptom burden were associated with long‐term work participation and may help identify patients at risk of not working after surgery.
SN  - 2475-0328
ER  -