Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial
Abstract
Aims: To evaluate 6-month effects of a multi-ingredient nutritional powder formulation targeting complementary pathways relevant to vascular ageing on endothelial function and other vascular ageing markers in apparently healthy adults.
Methods and results: The effects of a supplement to target ageing mechanisms on vascular function study was a double-blind, randomized, controlled trial. Participants received a multi-ingredient nutritional powder formulation comprising vitamins/minerals, amino acids, and plant-derived bioactives, or control for 6 months. Vascular assessments were performed at baseline and after 6 months (with an acute post-dose assessment). The primary outcome was change in brachial artery flow-mediated dilation (FMD). Secondary outcomes included pulse wave velocity (PWV), peripheral and central blood pressure, augmentation index, lipid profile, and estimated 10-year cardiovascular risk (SCORE2/SCORE2-OP). Sixty-one participants (baseline SCORE2/SCORE2-OP 3.6 ± 2.9%) were randomized (33 actives; 28 controls); 43 completed both visits (24 vs. 19). Compared with control, the supplement improved endothelial function (ΔΔFMD at 6 months +2.9% [95% CI 2.1–3.8]) and reduced arterial stiffness (ΔΔPWV −1.18 m/s [95% CI −2.00 to −0.36]). Peripheral systolic blood pressure (SBP) decreased (ΔΔSBP −6.1 mmHg [95% CI −10.9 to −1.3]). Lipids were unchanged. Estimated 10-year cardiovascular risk decreased (ΔΔSCORE2/SCORE2-OP −0.45% [95% CI −0.86 to −0.03]).
Conclusion: Daily intake of a multi-ingredient nutritional powder formulation was associated with sustained improvements in endothelial function, arterial stiffness, and systolic blood pressure, with a modest reduction in estimated 10-year cardiovascular risk primarily attributable to lower systolic blood pressure rather than lipid change.
Registration: clinicaltrials.gov NCT06145087.
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BibTeX
@article{piercy2026acute,
title = {{Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial}},
author = {Charles Piercy and Jenny Harris and Kenza Sackho and Paola Campagnolo and Diogo Barardo and Ben Creagh-Brown and Christian Heiss},
journal = {European heart journal open},
year = {2026},
month = nov,
doi = {10.1093/ehjopen/oeag157},
url = {https://europepmc.org/article/PMC/PMC13730552},
note = {CC BY},
}
RIS
TY - JOUR
TI - Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial
AU - Charles Piercy
AU - Jenny Harris
AU - Kenza Sackho
AU - Paola Campagnolo
AU - Diogo Barardo
AU - Ben Creagh-Brown
AU - Christian Heiss
PY - 2026
DA - 2026/11/01
JO - European heart journal open
DO - 10.1093/ehjopen/oeag157
UR - https://europepmc.org/article/PMC/PMC13730552
AB - Aims: To evaluate 6-month effects of a multi-ingredient nutritional powder formulation targeting complementary pathways relevant to vascular ageing on endothelial function and other vascular ageing markers in apparently healthy adults. Methods and results: The effects of a supplement to target ageing mechanisms on vascular function study was a double-blind, randomized, controlled trial. Participants received a multi-ingredient nutritional powder formulation comprising vitamins/minerals, amino acids, and plant-derived bioactives, or control for 6 months. Vascular assessments were performed at baseline and after 6 months (with an acute post-dose assessment). The primary outcome was change in brachial artery flow-mediated dilation (FMD). Secondary outcomes included pulse wave velocity (PWV), peripheral and central blood pressure, augmentation index, lipid profile, and estimated 10-year cardiovascular risk (SCORE2/SCORE2-OP). Sixty-one participants (baseline SCORE2/SCORE2-OP 3.6 ± 2.9%) were randomized (33 actives; 28 controls); 43 completed both visits (24 vs. 19). Compared with control, the supplement improved endothelial function (ΔΔFMD at 6 months +2.9% [95% CI 2.1–3.8]) and reduced arterial stiffness (ΔΔPWV −1.18 m/s [95% CI −2.00 to −0.36]). Peripheral systolic blood pressure (SBP) decreased (ΔΔSBP −6.1 mmHg [95% CI −10.9 to −1.3]). Lipids were unchanged. Estimated 10-year cardiovascular risk decreased (ΔΔSCORE2/SCORE2-OP −0.45% [95% CI −0.86 to −0.03]). Conclusion: Daily intake of a multi-ingredient nutritional powder formulation was associated with sustained improvements in endothelial function, arterial stiffness, and systolic blood pressure, with a modest reduction in estimated 10-year cardiovascular risk primarily attributable to lower systolic blood pressure rather than lipid change. Registration: clinicaltrials.gov NCT06145087.
SN - 2752-4191
ER -