Skip to content
DraconiticResearch
Search Sources API
185,139 studies31 sourcesUpdated 42 min ago
Peer-reviewedCC BY-NC-ND中国当代儿科杂志

Expression patterns of fecal iron metabolism-related proteins in infants with food allergy

  • ZHOU Zi-Bei1
  • ZHANG Juan1
  • LI Zai-Ling1
  1. 1Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China
Read full textPDFDOICite

Abstract

ObjectiveTo investigate the expression patterns of fecal iron metabolism-related proteins at the early stage of food allergy (FA) onset in infants, and to explore the association between imbalance of local intestinal iron homeostasis and infant FA.MethodsA nested case-control design within a prospective clinical cohort was used. From October 2024 to June 2025, 162 infants with suspected FA were recruited from outpatient clinics, the child health department, and community settings, and classified into an FA group (n=88) and a non-FA group (n=74) according to standardized oral food challenge results. Baseline fecal samples collected prior to diagnosis were tested by enzyme-linked immunosorbent assay for iron metabolism-related proteins, and fecal non-heme iron content was measured. Group differences were compared.ResultsFA onset peaked at 4-6 months of age, coinciding with the period of physiological depletion of fetal iron stores. Gastrointestinal symptoms predominated. Compared with the non-FA group, the FA group had significantly higher fecal transferrin receptor 1 concentrations (P<0.001) and significantly lower ferritin heavy chain, ferritin light chain, and non-heme iron content (all P<0.05). No significant between-group differences were observed in lactoferrin or hephaestin concentrations (P>0.05).ConclusionsInfants with FA exhibit an imbalance of local intestinal iron homeostasis at the early stage of disease onset, characterized by enhanced iron uptake signaling alongside reduced iron storage, indicative of a functional iron deficiency state. This imbalance appears associated with the early occurrence of infant FA.

Related

  1. Comparative transcriptome analysis of galls induced by four closely related aphid species using the draft genome of the host plant (Hamamelis japonica) reveals gene expression patterns related to gall diversification
    Mayu MIZUKI, Michiko SASABE, Hiroshi IKEDA
    BMC GenomicsPeer-reviewedCC BY 4.0Genetics & genomicsCrossref
  2. Smart scaffolds: how WD40 proteins integrate plant development, metabolism and stress adaptation
    Chandan Roy, Shuvobrata Majumder, Salman Sahid
    Annals of BotanyPeer-reviewedPublisher termsFull textPlant biologyPMC
  3. Genetic analyses reveal distinct functional roles of Eut microcompartment shell proteins in ethanolamine metabolism in Salmonella
    M. R. Bhalerao, A. A. Sutar, A. S. Davkhar +3
    bioRxivPreprintCC BY-NC-NDFull textMicrobiologybioRxiv
  4. Interactions between kidney proteins and metabolism in Tibetan sheep at different altitudes.
    Kejiang Liu, Jiang Zhang, Xueqin Yu +1
    BMC genomicsPeer-reviewedCC BY-NC-NDFull textGenetics & genomicsEurope PMCDOAJ
  5. Agrochemical-responsive gene expression control systems for modulating plant development and metabolism
    T. A. Bull, L. Farina, S. Sutton +3
    bioRxivPreprintAll rights reservedFull textSystems & synthetic biologybioRxiv

Cite

BibTeXRIS
BibTeX
@article{zibei2026expression,
  title = {{Expression patterns of fecal iron metabolism-related proteins in infants with food allergy}},
  author = {ZHOU Zi-Bei and ZHANG Juan and LI Zai-Ling},
  journal = {中国当代儿科杂志},
  year = {2026},
  month = oct,
  doi = {10.7499/j.issn.1008-8830.2601154},
  url = {https://doi.org/10.7499/j.issn.1008-8830.2601154},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Expression patterns of fecal iron metabolism-related proteins in infants with food allergy
AU  - ZHOU Zi-Bei
AU  - ZHANG Juan
AU  - LI Zai-Ling
PY  - 2026
DA  - 2026/10/23
JO  - 中国当代儿科杂志
DO  - 10.7499/j.issn.1008-8830.2601154
UR  - https://doi.org/10.7499/j.issn.1008-8830.2601154
AB  - ObjectiveTo investigate the expression patterns of fecal iron metabolism-related proteins at the early stage of food allergy (FA) onset in infants, and to explore the association between imbalance of local intestinal iron homeostasis and infant FA.MethodsA nested case-control design within a prospective clinical cohort was used. From October 2024 to June 2025, 162 infants with suspected FA were recruited from outpatient clinics, the child health department, and community settings, and classified into an FA group (n=88) and a non-FA group (n=74) according to standardized oral food challenge results. Baseline fecal samples collected prior to diagnosis were tested by enzyme-linked immunosorbent assay for iron metabolism-related proteins, and fecal non-heme iron content was measured. Group differences were compared.ResultsFA onset peaked at 4-6 months of age, coinciding with the period of physiological depletion of fetal iron stores. Gastrointestinal symptoms predominated. Compared with the non-FA group, the FA group had significantly higher fecal transferrin receptor 1 concentrations (P<0.001) and significantly lower ferritin heavy chain, ferritin light chain, and non-heme iron content (all P<0.05). No significant between-group differences were observed in lactoferrin or hephaestin concentrations (P>0.05).ConclusionsInfants with FA exhibit an imbalance of local intestinal iron homeostasis at the early stage of disease onset, characterized by enhanced iron uptake signaling alongside reduced iron storage, indicative of a functional iron deficiency state. This imbalance appears associated with the early occurrence of infant FA.
SN  - 1008-8830
SN  - 2096-9228
ER  -