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Peer-reviewedCC BY 4.0PLOS One

Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test

  • Karlijn Demers1
  • Sander M. J. van Kuijk2
  • Marieke J. Pierik3
  • Daisy M. A. E. Jonkers4
  • Laurents P. S. Stassen5
  • Bart C. Bongers6
6 affiliations
  1. 1.Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands
  2. 2.Department of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands
  3. 3.Department of Surgery, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands
  4. 4.Department of Gastroenterology-Hepatology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands
  5. 5.Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center+, Maastricht, the Netherlands
  6. 6.Department of Nutrition and Movement Sciences, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands
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Abstract

Purpose: To develop predictive equations for oxygen uptake at peak exercise (VO2peak) measured during a cardiopulmonary exercise test (CPET) for patients with inflammatory bowel disease (IBD) using submaximal CPET-derived parameters and the steep ramp test, along with demographic and clinical characteristics. Methods: This study included patients with IBD in remission or with mild-to-moderate disease activity who performed a CPET and a steep ramp test within 14 days. Submaximal CPET-derived parameters included oxygen uptake (VO2) at the ventilatory anaerobic threshold (VAT) and oxygen uptake efficiency slope (OUES), while the outcome of the steep ramp test was the work rate achieved at peak exercise (WRpeak). Results: Predictive regression equations with submaximal VO2 at the VAT and with OUES, when combined with age and body fat percentage, explained >89% of the variance in VO2peak (optimism-adjusted R2 = 0.895 and 0.938). Predictive capacity increased when both VO2 at the VAT and OUES were combined in a predictive regression equation, together with age, body fat percentage, and clinically active disease (optimism-adjusted R2 = 0.951). Steep ramp test WRpeak explained 89% of the variance in VO2peak (optimism-adjusted R2 = 0.892). Conclusion: The highly predictive equations developed in this study support the use of the submaximal CPET and the steep ramp test as alternatives for assessing VO2peak in patients with IBD in remission or with mild-to-moderate disease activity in clinical and research settings.

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Cite

BibTeXRIS
BibTeX
@article{demers2026prediction,
  title = {{Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test}},
  author = {Karlijn Demers and Sander M. J. van Kuijk and Marieke J. Pierik and Daisy M. A. E. Jonkers and Laurents P. S. Stassen and Bart C. Bongers},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0354707},
  url = {https://doi.org/10.1371/journal.pone.0354707},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test
AU  - Karlijn Demers
AU  - Sander M. J. van Kuijk
AU  - Marieke J. Pierik
AU  - Daisy M. A. E. Jonkers
AU  - Laurents P. S. Stassen
AU  - Bart C. Bongers
PY  - 2026
DA  - 2026/10/08
JO  - PLOS One
DO  - 10.1371/journal.pone.0354707
UR  - https://doi.org/10.1371/journal.pone.0354707
AB  - Purpose: To develop predictive equations for oxygen uptake at peak exercise (VO2peak) measured during a cardiopulmonary exercise test (CPET) for patients with inflammatory bowel disease (IBD) using submaximal CPET-derived parameters and the steep ramp test, along with demographic and clinical characteristics. Methods: This study included patients with IBD in remission or with mild-to-moderate disease activity who performed a CPET and a steep ramp test within 14 days. Submaximal CPET-derived parameters included oxygen uptake (VO2) at the ventilatory anaerobic threshold (VAT) and oxygen uptake efficiency slope (OUES), while the outcome of the steep ramp test was the work rate achieved at peak exercise (WRpeak). Results: Predictive regression equations with submaximal VO2 at the VAT and with OUES, when combined with age and body fat percentage, explained >89% of the variance in VO2peak (optimism-adjusted R2 = 0.895 and 0.938). Predictive capacity increased when both VO2 at the VAT and OUES were combined in a predictive regression equation, together with age, body fat percentage, and clinically active disease (optimism-adjusted R2 = 0.951). Steep ramp test WRpeak explained 89% of the variance in VO2peak (optimism-adjusted R2 = 0.892). Conclusion: The highly predictive equations developed in this study support the use of the submaximal CPET and the steep ramp test as alternatives for assessing VO2peak in patients with IBD in remission or with mild-to-moderate disease activity in clinical and research settings.
SN  - 1932-6203
ER  -