Fast and compact scatterometer for low-scattering biological samples

Abstract

We present the design, calibration, qualification, and application of a fast and compact scatterometer designed for the characterization of ex-vivo human corneas. As an alternative to standard qualification processes, and in order to meet the current need for improved reliability of graft qualification, this instrument provides a non-invasive, label-free and contact-free, quantitative mean of characterizing corneal grafts, based on back-scattered light diffusometry. The instrument is shown to be capable of detecting BRDF (bidirectional reflectance distribution function) variations of 1.4× 10 -4 sr -1 with a detectivity threshold of 2.0 × 10 -3 sr -1 , with an overall dynamics > 27 dB for the Total Integrated Scattering (TIS) parameter used for graft quality assessment. We also demonstrate the feasibility of integrating this new technique into tissue bank qualification processes, through controlled test experiments reported here.

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Cite

BibTeX RIS

BibTeX

@article{sarrade2026fast,
  title = {{Fast and compact scatterometer for low-scattering biological samples}},
  author = {A Sarrade and J El Allam and V Espinas and L Hoffart and C Picard and T David and G Georges and C Deumié and L Siozade Lamoine and J Fade},
  journal = {Review of Scientific Instruments},
  year = {2026},
  month = oct,
  doi = {10.1063/5.0327390},
  url = {https://hal.science/hal-05490843v3},
  note = {CC BY-SA 4.0},
}

RIS

TY  - JOUR
TI  - Fast and compact scatterometer for low-scattering biological samples
AU  - A Sarrade
AU  - J El Allam
AU  - V Espinas
AU  - L Hoffart
AU  - C Picard
AU  - T David
AU  - G Georges
AU  - C Deumié
AU  - L Siozade Lamoine
AU  - J Fade
PY  - 2026
DA  - 2026/10/07
JO  - Review of Scientific Instruments
DO  - 10.1063/5.0327390
UR  - https://hal.science/hal-05490843v3
AB  - We present the design, calibration, qualification, and application of a fast and compact scatterometer designed for the characterization of ex-vivo human corneas. As an alternative to standard qualification processes, and in order to meet the current need for improved reliability of graft qualification, this instrument provides a non-invasive, label-free and contact-free, quantitative mean of characterizing corneal grafts, based on back-scattered light diffusometry. The instrument is shown to be capable of detecting BRDF (bidirectional reflectance distribution function) variations of 1.4× 10 -4 sr -1 with a detectivity threshold of 2.0 × 10 -3 sr -1 , with an overall dynamics > 27 dB for the Total Integrated Scattering (TIS) parameter used for graft quality assessment. We also demonstrate the feasibility of integrating this new technique into tissue bank qualification processes, through controlled test experiments reported here.
SN  - 0034-6748
SN  - 1089-7623
ER  -

Abstract

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