Gastrointestinal tract delivery of hydrogen by dynamic gas-releasing frameworks
Abstract
Given the broad therapeutic benefits of molecular hydrogen, gastrointestinal delivery of this gasotransmitter is attractive for treating localized inflammatory diseases, yet conventional H2-releasing formulations suffer from limited solubility and poor tunability. Here, we develop gas-releasing frameworks (GRFs) for effective H2 delivery to the gastrointestinal tract. GRFs provide 20,000-fold higher hydrogen storage than hydrogen-rich water (HRW), prevent burst leakage in acidic gastric fluid, and enable sustained, inflammation-targeted H2 release in the intestine. After H2 release, the dynamic framework sequesters toxic boron within a reconstituted Si-O-B architecture, promoting fecal rather than systemic boron accumulation and improving long-term biosafety. Consequently, GRFs outperform HRW in mitigating oxidative damage and inflammation in dextran sulfate sodium-induced colitis, radiation-induced colitis, and high-fat diet-induced non-alcoholic fatty liver disease. Collectively, these gas-releasing frameworks provide a feasible, safe, and translatable strategy for gastrointestinal delivery of therapeutic gases and treatment of inflammatory disorders.
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BibTeX
@article{lu2026gastrointestinal,
title = {{Gastrointestinal tract delivery of hydrogen by dynamic gas-releasing frameworks}},
author = {Junna Lu and Xiaochun Xie and Chao Yang and Yidan Zhang and Xin Zhao and Huanfen Lu and Madi Sun and Fangman Chen and Yingshuai Wang and Dan Shao and Kam W. Leong and He Shen},
journal = {Nature Communications},
year = {2026},
month = oct,
doi = {10.1038/s41467-026-78290-6},
url = {https://www.nature.com/articles/s41467-026-78290-6},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Gastrointestinal tract delivery of hydrogen by dynamic gas-releasing frameworks
AU - Junna Lu
AU - Xiaochun Xie
AU - Chao Yang
AU - Yidan Zhang
AU - Xin Zhao
AU - Huanfen Lu
AU - Madi Sun
AU - Fangman Chen
AU - Yingshuai Wang
AU - Dan Shao
AU - Kam W. Leong
AU - He Shen
PY - 2026
DA - 2026/10/06
JO - Nature Communications
DO - 10.1038/s41467-026-78290-6
UR - https://www.nature.com/articles/s41467-026-78290-6
AB - Given the broad therapeutic benefits of molecular hydrogen, gastrointestinal delivery of this gasotransmitter is attractive for treating localized inflammatory diseases, yet conventional H2-releasing formulations suffer from limited solubility and poor tunability. Here, we develop gas-releasing frameworks (GRFs) for effective H2 delivery to the gastrointestinal tract. GRFs provide 20,000-fold higher hydrogen storage than hydrogen-rich water (HRW), prevent burst leakage in acidic gastric fluid, and enable sustained, inflammation-targeted H2 release in the intestine. After H2 release, the dynamic framework sequesters toxic boron within a reconstituted Si-O-B architecture, promoting fecal rather than systemic boron accumulation and improving long-term biosafety. Consequently, GRFs outperform HRW in mitigating oxidative damage and inflammation in dextran sulfate sodium-induced colitis, radiation-induced colitis, and high-fat diet-induced non-alcoholic fatty liver disease. Collectively, these gas-releasing frameworks provide a feasible, safe, and translatable strategy for gastrointestinal delivery of therapeutic gases and treatment of inflammatory disorders.
SN - 2041-1723
ER -