Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study

@article{maasen2026higher,
  title = {{Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study}},
  author = {Kim Maasen and Ana-Lucia Mayen and Claudia Hana and Viktoria Knaze and Marleen M. J. van Greevenbroek and Simone J. P. M. Eussen and Charlotte Debras and Coen D. A. Stehouwer and Anne Tjønneland and Cecilie Kyrø and Daniel B. Ibsen and Christina C. Dah and Francesca Mancini and Nasser Laouali and Mariem Hajji and Matthias B. Schulze and Rashmita Bajracharya and Verena Katzke and Giovanna Masala and Fabrizio Pasanisi and Lorenzo Milani and Valeria Pala and Marta Farràs Mañé and Conchi Moreno-Iribas and Miguel Rodriguez-Barranco and Sandra Milena Colorado Yohar and Olatz Mokoroa and Keren Papier and Elisabete Weiderpass and Heinz Freisling and Nicholas J. Wareham and Nita G. Forouhi and Sofia Christakoudi and Philippe Vangrieken and Mazda Jenab and Casper G. Schalkwijk},
  journal = {European Journal of Nutrition},
  year = {2026},
  month = nov,
  doi = {10.1007/s00394-026-03904-0},
  url = {https://hal.science/hal-05849872v1},
  note = {CC BY},
}

TY  - JOUR
TI  - Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study
AU  - Kim Maasen
AU  - Ana-Lucia Mayen
AU  - Claudia Hana
AU  - Viktoria Knaze
AU  - Marleen M. J. van Greevenbroek
AU  - Simone J. P. M. Eussen
AU  - Charlotte Debras
AU  - Coen D. A. Stehouwer
AU  - Anne Tjønneland
AU  - Cecilie Kyrø
AU  - Daniel B. Ibsen
AU  - Christina C. Dah
AU  - Francesca Mancini
AU  - Nasser Laouali
AU  - Mariem Hajji
AU  - Matthias B. Schulze
AU  - Rashmita Bajracharya
AU  - Verena Katzke
AU  - Giovanna Masala
AU  - Fabrizio Pasanisi
AU  - Lorenzo Milani
AU  - Valeria Pala
AU  - Marta Farràs Mañé
AU  - Conchi Moreno-Iribas
AU  - Miguel Rodriguez-Barranco
AU  - Sandra Milena Colorado Yohar
AU  - Olatz Mokoroa
AU  - Keren Papier
AU  - Elisabete Weiderpass
AU  - Heinz Freisling
AU  - Nicholas J. Wareham
AU  - Nita G. Forouhi
AU  - Sofia Christakoudi
AU  - Philippe Vangrieken
AU  - Mazda Jenab
AU  - Casper G. Schalkwijk
PY  - 2026
DA  - 2026/11/03
JO  - European Journal of Nutrition
DO  - 10.1007/s00394-026-03904-0
UR  - https://hal.science/hal-05849872v1
AB  - PURPOSE: Dicarbonyls are reactive precursors of advanced glycation end-products. They are formed during food processing, and endogenously in humans during glycolysis and lipid peroxidation. Higher plasma dicarbonyls, particularly methylglyoxal (MGO), promote insulin resistance and type 2 diabetes, but the association between dietary dicarbonyls intake and type 2 diabetes is unknown. This study examined the associations between dietary dicarbonyls and type 2 diabetes incidence. METHODS: 11,995 incident type 2 diabetes cases and a sub-cohort of 15,797 controls from the prospective multi-center European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct cohort were included. Intakes of three major dicarbonyls MGO, glyoxal [GO], and 3-deoxyglucosone [3-DG] were estimated at baseline using dietary questionnaires. Type 2 diabetes risk according to dietary dicarbonyl intake was estimated by multivariable-adjusted hazard ratios from Prentice-weighted Cox-regression analyses. RESULTS: Higher intakes of MGO (sample-specific mean intake 3.4 ± 1.3 mg/d) and 3-DG (13.8 ± 10.5) were associated with lower incidence of type 2 diabetes (HR 0.92 [95% CI 0.90–0.95] for 1 SD higher MGO intake and 0.93 [0.90–0.95] for 1 SD higher 3-DG intake). No associations were observed for dietary GO. CONCLUSION: Participants who consumed more dietary dicarbonyls MGO and 3-DG had a lower risk to develop type 2 diabetes. This protective association contrasts with the harmful effects on type 2 diabetes risk reported for endogenously formed dicarbonyls.
SN  - 1436-6207
SN  - 1436-6215
ER  -