Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones.
- 1Department of Chemistry Education, Faculty of Education, Ondokuz Mayıs University, Samsun, Türkiye.
- 2Department of Chemistry, Faculty of Sciences, Kastamonu University, Kastamonu, Türkiye.
- 3Department of Chemistry, Faculty of Sciences, Ondokuz Mayıs University, Samsun, Türkiye.
Abstract
New thiosemicarbazones bearing Schiff base (1-7) were prepared from 4-(dimethylamino)benzaldehyde and thiosemicarbazides. The reaction of various isothiocyanates with hydrazine monohydrate resulted in the thiosemicarbazides. The structural frameworks of the newly developed derivatives were confirmed by elemental analysis and conventional spectroscopic methods, namely, FT-IR, ¹H, and ¹³C NMR. The in vitro antioxidant activity of the synthesized series was evaluated using the DPPH• (1,1-diphenyl-2-picrylhydrazyl) scavenging method. The results indicated that the inhibitory concentrations (IC₅₀) of the compounds ranged from 8.50 ± 0.14 to 31.44 ± 1.39 µg/mL, with compound 6 exhibiting the most potent antioxidant activity. Additionally, the inhibitory activities of urease and xanthine oxidase (XO) were assessed, and the interactions of the compounds with these enzymes were also analyzed. Molecular docking was performed to assess the interactions between each molecule and the active sites of urease and XO.
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BibTeX
@article{yakan2026preparation,
title = {{Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones.}},
author = {Hasan Yakan and Halit Muglu and Semiha Yenigun and Tevfik Ozen},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71882},
url = {https://europepmc.org/article/MED/42960721},
note = {CC BY},
}
RIS
TY - JOUR
TI - Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones.
AU - Hasan Yakan
AU - Halit Muglu
AU - Semiha Yenigun
AU - Tevfik Ozen
PY - 2026
DA - 2026/10/30
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71882
UR - https://europepmc.org/article/MED/42960721
AB - New thiosemicarbazones bearing Schiff base (1-7) were prepared from 4-(dimethylamino)benzaldehyde and thiosemicarbazides. The reaction of various isothiocyanates with hydrazine monohydrate resulted in the thiosemicarbazides. The structural frameworks of the newly developed derivatives were confirmed by elemental analysis and conventional spectroscopic methods, namely, FT-IR, ¹H, and ¹³C NMR. The in vitro antioxidant activity of the synthesized series was evaluated using the DPPH• (1,1-diphenyl-2-picrylhydrazyl) scavenging method. The results indicated that the inhibitory concentrations (IC₅₀) of the compounds ranged from 8.50 ± 0.14 to 31.44 ± 1.39 µg/mL, with compound 6 exhibiting the most potent antioxidant activity. Additionally, the inhibitory activities of urease and xanthine oxidase (XO) were assessed, and the interactions of the compounds with these enzymes were also analyzed. Molecular docking was performed to assess the interactions between each molecule and the active sites of urease and XO.
SN - 1612-1872
SN - 1612-1880
ER -