Skip to content
DraconiticResearch
Search Sources API
185,139 studies31 sourcesUpdated 43 min ago
Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Correlates of the Lumbar–Femoral T-Score Difference in Older Adults: Sex Outweighs the Triglyceride–Glucose Index

  • Rıdvan Erten1
  • Kübra Erdoğan2
  • Mehmet Poyrazer3
  • Özgür Çakır4
  • Rana Tuna Doğrul2
  • Hande Selvi Öztorun5
  • Kamile Sılay5
5 affiliations
  1. 1Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, 41380 Kocaeli, Türkiye
  2. 2Geriatrics Clinic, Ankara Bilkent City Hospital, 06800 Ankara, Türkiye
  3. 3Division of Endocrinology and Metabolism, University of Health Sciences Ankara Training and Research Hospital, 06230 Ankara, Türkiye
  4. 4Department of Radiology, Faculty of Medicine, Kocaeli University, 41380 Kocaeli, Türkiye
  5. 5Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Ankara Yıldırım Beyazıt University, 06800 Ankara, Türkiye
Read full textPDFDOICite

Abstract

Background/Objectives: We examined correlates of lumbar–femoral T-score differences (ΔT), retaining the triglyceride–glucose (TyG) index as the prespecified primary exposure. Methods: This retrospective cross-sectional analysis of routine records included 528 geriatric outpatients assessed in Ankara, Türkiye, in 2023; primary regression used 506 complete cases. ΔT was lumbar minus femoral-neck T-score. Device L1–L4 composites were used without vertebra-level exclusions because scan images were unavailable. Firth models and an exploratory post hoc arithmetic decomposition were secondary. Results: Male sex was associated with higher ΔT (B = +0.984; p < 0.001), uniquely explaining 9.87% of variance versus 0.88% for TyG. TyG estimates (95% CI) were +0.243 (+0.033 to +0.453; p = 0.023) in the primary analysis, +0.214 (−0.010 to +0.438; p = 0.061) retaining two records excluded by plausibility limits, and +0.070 (−0.115 to +0.255; p = 0.458) excluding influential observations. The male lumbar-worse OR was 0.12 (95% CI 0.03–0.31), based on 3/165 male events. Among patients with femoral-neck osteoporosis, lumbar T-scores exceeded −2.5 in 22/30 men versus 43/89 women (post hoc, unadjusted). Conclusions: Sex explained more unique ΔT variance than TyG. The TyG association was small and sensitive to analytic decisions. Unmeasured degeneration and selection bias limit interpretation.

Related

  1. Association between the triglyceride-glucose index and carotid-femoral pulse wave velocity in rural hypertensive adults
    Zaihua Cheng, Lan Gao, Xudong Hu +9
    BMC Cardiovascular DisordersPeer-reviewedCC BYFull textCardiovascular medicineDOAJ
  2. Association of the triglyceride-glucose index and triglyceride-glucose-body mass index with postoperative atrial fibrillation in patients undergoing off-pump coronary artery bypass grafting: a retrospective cohort study
    Zhiyuan Song, Jiawei Wu, Ze Bu +6
    Journal of thoracic diseasePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  3. Association of triglyceride-glucose and its related indices with circadian syndrome : Evidence from a prospective cohort study
    MedicinePeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  4. Changes in CGM-Derived Glycemic Metrics and Triglyceride-Glucose Index During Ramadan in Adults With Type 2 Diabetes Using Real-Time Continuous Glucose Monitoring
    Ayman Al Hayek, Wael M. Al Zahrani, Mo’men Al Ajlouni +2
    Journal of Diabetes Science and TechnologyPeer-reviewedLicence not statedFull textPhysiologyPMC
  5. Association between triglyceride glucose–relative fat mass index and obstructive sleep apnea risk : A cross-sectional study from NHANES
    Yunzhou Zheng, Shanshan Zhang, Mingqiang Mi
    MedicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{erten2026correlates,
  title = {{Correlates of the Lumbar–Femoral T-Score Difference in Older Adults: Sex Outweighs the Triglyceride–Glucose Index}},
  author = {Rıdvan Erten and Kübra Erdoğan and Mehmet Poyrazer and Özgür Çakır and Rana Tuna Doğrul and Hande Selvi Öztorun and Kamile Sılay},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15207773},
  url = {https://www.mdpi.com/2077-0383/15/20/7773},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Correlates of the Lumbar–Femoral T-Score Difference in Older Adults: Sex Outweighs the Triglyceride–Glucose Index
AU  - Rıdvan Erten
AU  - Kübra Erdoğan
AU  - Mehmet Poyrazer
AU  - Özgür Çakır
AU  - Rana Tuna Doğrul
AU  - Hande Selvi Öztorun
AU  - Kamile Sılay
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15207773
UR  - https://www.mdpi.com/2077-0383/15/20/7773
AB  - Background/Objectives: We examined correlates of lumbar–femoral T-score differences (ΔT), retaining the triglyceride–glucose (TyG) index as the prespecified primary exposure. Methods: This retrospective cross-sectional analysis of routine records included 528 geriatric outpatients assessed in Ankara, Türkiye, in 2023; primary regression used 506 complete cases. ΔT was lumbar minus femoral-neck T-score. Device L1–L4 composites were used without vertebra-level exclusions because scan images were unavailable. Firth models and an exploratory post hoc arithmetic decomposition were secondary. Results: Male sex was associated with higher ΔT (B = +0.984; p < 0.001), uniquely explaining 9.87% of variance versus 0.88% for TyG. TyG estimates (95% CI) were +0.243 (+0.033 to +0.453; p = 0.023) in the primary analysis, +0.214 (−0.010 to +0.438; p = 0.061) retaining two records excluded by plausibility limits, and +0.070 (−0.115 to +0.255; p = 0.458) excluding influential observations. The male lumbar-worse OR was 0.12 (95% CI 0.03–0.31), based on 3/165 male events. Among patients with femoral-neck osteoporosis, lumbar T-scores exceeded −2.5 in 22/30 men versus 43/89 women (post hoc, unadjusted). Conclusions: Sex explained more unique ΔT variance than TyG. The TyG association was small and sensitive to analytic decisions. Unmeasured degeneration and selection bias limit interpretation.
SN  - 2077-0383
ER  -