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Peer-reviewedCC BYFrontiers in Bioengineering and Biotechnology

Biomaterials in the management of cleft lip and palate: current applications and future directions

  • Kangzhe Wang1
  • Kangzhe Wang2
  • Xiang Li1
  • Xiang Li2
  • Xueni Zhao3
  • Xu Cheng1
  • Lixian Chen1
  • Lixian Chen2
  • Hanyao Huang1
  • Hanyao Huang2
  1. 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China
  2. 2Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China
  3. 3Department of Otorhinolaryngology, Head and Neck Surgery, Division of Speech Intervention, The Chinese University of Hong Kong, Hong Kong SAR, China
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Abstract

Cleft lip and palate (CL/P) management spans diverse developmental phases, imposing dynamic requirements on adjunctive biomaterials. Although these materials hold significant promise for wound closure, infection control, fibrosis mitigation, tissue replacement, and drug delivery, their translation remains largely preclinical and uneven. The principal challenge lies in matching material design to specific surgical problems, necessitating rigorous indication-specific validation. To clarify this landscape, this review organizes the evidence around primary repair, secondary reconstruction, and prenatal or experimental applications, distinguishing established practices from emerging concepts to define design requirements for future translation.

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Cite

BibTeXRIS
BibTeX
@article{wang2026biomaterials,
  title = {{Biomaterials in the management of cleft lip and palate: current applications and future directions}},
  author = {Kangzhe Wang and Kangzhe Wang and Xiang Li and Xiang Li and Xueni Zhao and Xu Cheng and Lixian Chen and Lixian Chen and Hanyao Huang and Hanyao Huang},
  journal = {Frontiers in Bioengineering and Biotechnology},
  year = {2026},
  month = nov,
  doi = {10.3389/fbioe.2026.1992200},
  url = {https://doi.org/10.3389/fbioe.2026.1992200},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Biomaterials in the management of cleft lip and palate: current applications and future directions
AU  - Kangzhe Wang
AU  - Kangzhe Wang
AU  - Xiang Li
AU  - Xiang Li
AU  - Xueni Zhao
AU  - Xu Cheng
AU  - Lixian Chen
AU  - Lixian Chen
AU  - Hanyao Huang
AU  - Hanyao Huang
PY  - 2026
DA  - 2026/11/04
JO  - Frontiers in Bioengineering and Biotechnology
DO  - 10.3389/fbioe.2026.1992200
UR  - https://doi.org/10.3389/fbioe.2026.1992200
AB  - Cleft lip and palate (CL/P) management spans diverse developmental phases, imposing dynamic requirements on adjunctive biomaterials. Although these materials hold significant promise for wound closure, infection control, fibrosis mitigation, tissue replacement, and drug delivery, their translation remains largely preclinical and uneven. The principal challenge lies in matching material design to specific surgical problems, necessitating rigorous indication-specific validation. To clarify this landscape, this review organizes the evidence around primary repair, secondary reconstruction, and prenatal or experimental applications, distinguishing established practices from emerging concepts to define design requirements for future translation.
SN  - 2296-4185
ER  -