Shenling Baizhu powder associated with alleviating inflammation and intestinal mucosal microbiota injury in mice with diarrhea induced by a lard diet and fatigued state
Abstract
The intestinal microbiota plays a crucial role in the onset of diarrhea and can be modulated through dietary changes. Shenling Baizhu powder (SLBZ) has been shown to regulate diarrhea. Thirty Kunming mice were randomly divided into a normal group (MCN), model group (MMD), and SLBZ group (MSLBZ). Diarrhea was induced by fatigue combined with a high-fat diet. After modeling, the MSLBZ group received 145.6 g/(kg·d) SLBZ for 7 days. Pathological examination of small intestine tissues, along with measurements of interleukin 6 (IL-6), interleukin 17 (IL-17), immunoglobulin A (sIgA), and mucin 2 (Muc2) levels, were conducted. The intestinal mucosa was extracted for high-throughput sequencing of 16S rRNA. In the MMD group, intestinal damage, lymphocyte infiltration, decreased sIgA, diarrhea, and a significant increase in Helicobacter were observed compared with the MCN group. After SLBZ treatment, the MSLBZ group exhibited improved body weight, reduced intestinal damage, decreased levels of IL-6, increased sIgA, and alleviated diarrhea. Compared with the MMD group, the abundance of Duncaniella freteri was significantly higher, while Helicobacter was markedly reduced. Correlation analysis showed that Duncaniella freteri was positively correlated with sIgA and Muc2 and negatively correlated with IL-6 and IL-17. SLBZ alleviates intestinal mucosal damage, reduces pro-inflammatory cytokines, enhances sIgA production, and restores the microbiota balance in mice with diarrhea.
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BibTeX
@article{huang2026shenling,
title = {{Shenling Baizhu powder associated with alleviating inflammation and intestinal mucosal microbiota injury in mice with diarrhea induced by a lard diet and fatigued state}},
author = {Wenjing HUANG and Jing LIU and Miao JIANG and Ying CAI and Zhoujin TAN},
journal = {Bioscience of Microbiota, Food and Health},
year = {2026},
month = oct,
doi = {10.12938/bmfh.2026-043},
url = {https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-043/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Shenling Baizhu powder associated with alleviating inflammation and intestinal mucosal microbiota injury in mice with diarrhea induced by a lard diet and fatigued state
AU - Wenjing HUANG
AU - Jing LIU
AU - Miao JIANG
AU - Ying CAI
AU - Zhoujin TAN
PY - 2026
DA - 2026/10/08
JO - Bioscience of Microbiota, Food and Health
DO - 10.12938/bmfh.2026-043
UR - https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-043/_article
AB - The intestinal microbiota plays a crucial role in the onset of diarrhea and can be modulated through dietary changes. Shenling Baizhu powder (SLBZ) has been shown to regulate diarrhea. Thirty Kunming mice were randomly divided into a normal group (MCN), model group (MMD), and SLBZ group (MSLBZ). Diarrhea was induced by fatigue combined with a high-fat diet. After modeling, the MSLBZ group received 145.6 g/(kg·d) SLBZ for 7 days. Pathological examination of small intestine tissues, along with measurements of interleukin 6 (IL-6), interleukin 17 (IL-17), immunoglobulin A (sIgA), and mucin 2 (Muc2) levels, were conducted. The intestinal mucosa was extracted for high-throughput sequencing of 16S rRNA. In the MMD group, intestinal damage, lymphocyte infiltration, decreased sIgA, diarrhea, and a significant increase in Helicobacter were observed compared with the MCN group. After SLBZ treatment, the MSLBZ group exhibited improved body weight, reduced intestinal damage, decreased levels of IL-6, increased sIgA, and alleviated diarrhea. Compared with the MMD group, the abundance of Duncaniella freteri was significantly higher, while Helicobacter was markedly reduced. Correlation analysis showed that Duncaniella freteri was positively correlated with sIgA and Muc2 and negatively correlated with IL-6 and IL-17. SLBZ alleviates intestinal mucosal damage, reduces pro-inflammatory cytokines, enhances sIgA production, and restores the microbiota balance in mice with diarrhea.
SN - 2186-3342
ER -