Morphological changes in liver tissue induced by high-frequency and ultrasonic coagulation in an experimental study
- 1Poltava State Medical University
Abstract
Objective.To investigate the morphological changes in liver tissue resulting from the local application of bipolar and ultrasonic electrocoagulators in an experimental setting.
Materia ls and methods. The study was conducted on two male pigs that underwent laparoscopic gallbladder removal with coagulation of the gallbladder bed; in one animal, this was performed using a LigaSure bipolar electrocoagulator, and in the other, using a Harmonic ultrasonic instrument. For microscopic examination, liver tissue samples were taken from the coagulation zone together with the adjacent macroscopically unchanged parenchyma.
Results. A comparative analysis of the morphological changes in liver tissue induced by the LigaSure bipolar electrocoagulator and the Harmonic ultrasonic scalpel revealed that the mechanisms by which haemostasis is achieved and the morphological changes in the parenchyma of this organ are fundamentally different. When the Harmonic coagulator is used, a clearly defined zone of coagulative necrosis is formed, with a ‘melting’ effect on collagenous structures, which ensures reliable haemostasis and cholestasis. Bipolar coagulation effectively complements this process, ensuring stable haemostasis through deep thermal occlusion of the vessels. Morphological findings confirm minimal damage to surrounding tissues, which allows these methods to be recommended for precision procedures on parenchymal organs, including the liver.
Conclusions. A comparative analysis has demonstrated that the use of high-energy bipolar (LigaSure) and ultrasonic (Harmonic) coagulators is pathomorphologically justified and a priority in liver surgery, as they minimise the area of delayed necrosis and stimulate an early regenerative response in hepatocytes.
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BibTeX
@article{korniychuk2026morphological,
title = {{Morphological changes in liver tissue induced by high-frequency and ultrasonic coagulation in an experimental study}},
author = {V. Y. Korniychuk and M. O. Dudchenko and V. I. Liakhovskyi and M. I. Kravtsiv and B. M. Fylenko},
journal = {Український журнал клінічної хірургії},
year = {2026},
month = oct,
doi = {10.26779/2786-832x.2026.5.80},
url = {https://doi.org/10.26779/2786-832x.2026.5.80},
note = {CC BY},
}
RIS
TY - JOUR
TI - Morphological changes in liver tissue induced by high-frequency and ultrasonic coagulation in an experimental study
AU - V. Y. Korniychuk
AU - M. O. Dudchenko
AU - V. I. Liakhovskyi
AU - M. I. Kravtsiv
AU - B. M. Fylenko
PY - 2026
DA - 2026/10/23
JO - Український журнал клінічної хірургії
DO - 10.26779/2786-832x.2026.5.80
UR - https://doi.org/10.26779/2786-832x.2026.5.80
AB - Objective.To investigate the morphological changes in liver tissue resulting from the local application of bipolar and ultrasonic electrocoagulators in an experimental setting. Materia ls and methods. The study was conducted on two male pigs that underwent laparoscopic gallbladder removal with coagulation of the gallbladder bed; in one animal, this was performed using a LigaSure bipolar electrocoagulator, and in the other, using a Harmonic ultrasonic instrument. For microscopic examination, liver tissue samples were taken from the coagulation zone together with the adjacent macroscopically unchanged parenchyma. Results. A comparative analysis of the morphological changes in liver tissue induced by the LigaSure bipolar electrocoagulator and the Harmonic ultrasonic scalpel revealed that the mechanisms by which haemostasis is achieved and the morphological changes in the parenchyma of this organ are fundamentally different. When the Harmonic coagulator is used, a clearly defined zone of coagulative necrosis is formed, with a ‘melting’ effect on collagenous structures, which ensures reliable haemostasis and cholestasis. Bipolar coagulation effectively complements this process, ensuring stable haemostasis through deep thermal occlusion of the vessels. Morphological findings confirm minimal damage to surrounding tissues, which allows these methods to be recommended for precision procedures on parenchymal organs, including the liver. Conclusions. A comparative analysis has demonstrated that the use of high-energy bipolar (LigaSure) and ultrasonic (Harmonic) coagulators is pathomorphologically justified and a priority in liver surgery, as they minimise the area of delayed necrosis and stimulate an early regenerative response in hepatocytes.
SN - 2786-832X
SN - 2786-8311
ER -