Familial Interstitial Pneumonia with Occupational Mixed Dust Exposure in a Dental Technician
Abstract
A 56-year-old man with a family history of interstitial lung disease and long-term occupational exposure to toxins as a dental technician presented with progressive dyspnea. High-resolution computed tomography revealed a usual interstitial pneumonia pattern (UIP). A surgical lung biopsy revealed UIP with fibroblastic foci and granulomatous lesions containing birefringent particles. An elemental analysis identified multiple inorganic elements, including silica and dental metals, but not cobalt or tungsten. Despite antifibrotic and anti-inflammatory therapy, the disease progressed rapidly, and the patient died while awaiting lung transplantation. These findings suggest that mixed-dust exposure may accelerate fibrosis in genetically susceptible patients with familial interstitial pneumonia.
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BibTeX
@article{sugino2026familial,
title = {{Familial Interstitial Pneumonia with Occupational Mixed Dust Exposure in a Dental Technician}},
author = {Keishi Sugino and Hirotaka Ono and Mikako Saito and Miho Kobayashi and Seiji Igarashi and Akira Hebisawa},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7928-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7928-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Familial Interstitial Pneumonia with Occupational Mixed Dust Exposure in a Dental Technician
AU - Keishi Sugino
AU - Hirotaka Ono
AU - Mikako Saito
AU - Miho Kobayashi
AU - Seiji Igarashi
AU - Akira Hebisawa
PY - 2026
DA - 2026/09/08
JO - Internal Medicine
DO - 10.2169/internalmedicine.7928-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7928-26/_article
AB - A 56-year-old man with a family history of interstitial lung disease and long-term occupational exposure to toxins as a dental technician presented with progressive dyspnea. High-resolution computed tomography revealed a usual interstitial pneumonia pattern (UIP). A surgical lung biopsy revealed UIP with fibroblastic foci and granulomatous lesions containing birefringent particles. An elemental analysis identified multiple inorganic elements, including silica and dental metals, but not cobalt or tungsten. Despite antifibrotic and anti-inflammatory therapy, the disease progressed rapidly, and the patient died while awaiting lung transplantation. These findings suggest that mixed-dust exposure may accelerate fibrosis in genetically susceptible patients with familial interstitial pneumonia.
SN - 1349-7235
SN - 0918-2918
ER -