Factors associated with chronicity in children with immune thrombocytopenia in Inner Mongolia
Abstract
To investigate the related factors influencing the progression of immune thrombocytopenia (ITP) to chronic immune thrombocytopenia (cITP) in children, aiming to evaluate their potential value in early risk stratification and prognosis assessment. Clinical data from pediatric ITP patients at 12 tertiary hospitals in Inner Mongolia, collected between January 2018 and September 2025 were analyzed. Through univariate and binary logistic regression analysis, we identified independent factors influencing the prognosis of children. (1) General information: A total of 549 patients were included, comprising 290 males (52.82%) and 259 females (47.18%), with a male-to-female ratio of 1.12:1. Among them, 146 (26.6%) developed chronic ITP, while 403 (73.4%) were non-chronic. (2) Univariate analysis showed that age, triggering factors (infection and/or vaccination), platelet count (PLT) at initial diagnosis, absolute lymphocyte count (ALC), T lymphocyte count, CD4⁺ T lymphocyte count, natural killer (NK) cell count, bone marrow megakaryocyte (MK) count, antinuclear antibody (ANA), and initial treatment modality were significantly associated with prognosis (P < 0.05). (3) Multivariate logistic regression revealed that age, CD4⁺ T lymphocyte count, and ANA positivity were independent factors for chronicity in pediatric ITP (P < 0.05). Children with ITP who were older at diagnosis and had a positive ANA were more likely to progress to chronic ITP; the higher CD4⁺ T lymphocyte counts may be protective. These factors may assist in early risk stratification and help identify patients requiring closer monitoring, thereby providing a reference for prognosis evaluation. However, their role in guiding individualized treatment strategies requires further validation in prospective studies.
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BibTeX
@article{wu2026factors,
title = {{Factors associated with chronicity in children with immune thrombocytopenia in Inner Mongolia}},
author = {Qi Wu and Kai-Li Fang and Na Zhang and Chen-Xin Zhang and Shao-Zhen Sheng and Yu-Wei Gu and Yan-Jun Wang and Rong Du and Li-Hua Ning and Qiang Chen and Xin Zhang and Ling-Yu Rong and Ling-Ling Liu and Xiu-Zhi Zhao and Xiao-Mei Zhang and Xiang-Wen Wang},
journal = {Scientific Reports},
year = {2026},
month = oct,
doi = {10.1038/s41598-026-52675-5},
url = {https://www.nature.com/articles/s41598-026-52675-5},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Factors associated with chronicity in children with immune thrombocytopenia in Inner Mongolia
AU - Qi Wu
AU - Kai-Li Fang
AU - Na Zhang
AU - Chen-Xin Zhang
AU - Shao-Zhen Sheng
AU - Yu-Wei Gu
AU - Yan-Jun Wang
AU - Rong Du
AU - Li-Hua Ning
AU - Qiang Chen
AU - Xin Zhang
AU - Ling-Yu Rong
AU - Ling-Ling Liu
AU - Xiu-Zhi Zhao
AU - Xiao-Mei Zhang
AU - Xiang-Wen Wang
PY - 2026
DA - 2026/10/22
JO - Scientific Reports
DO - 10.1038/s41598-026-52675-5
UR - https://www.nature.com/articles/s41598-026-52675-5
AB - To investigate the related factors influencing the progression of immune thrombocytopenia (ITP) to chronic immune thrombocytopenia (cITP) in children, aiming to evaluate their potential value in early risk stratification and prognosis assessment. Clinical data from pediatric ITP patients at 12 tertiary hospitals in Inner Mongolia, collected between January 2018 and September 2025 were analyzed. Through univariate and binary logistic regression analysis, we identified independent factors influencing the prognosis of children. (1) General information: A total of 549 patients were included, comprising 290 males (52.82%) and 259 females (47.18%), with a male-to-female ratio of 1.12:1. Among them, 146 (26.6%) developed chronic ITP, while 403 (73.4%) were non-chronic. (2) Univariate analysis showed that age, triggering factors (infection and/or vaccination), platelet count (PLT) at initial diagnosis, absolute lymphocyte count (ALC), T lymphocyte count, CD4⁺ T lymphocyte count, natural killer (NK) cell count, bone marrow megakaryocyte (MK) count, antinuclear antibody (ANA), and initial treatment modality were significantly associated with prognosis (P < 0.05). (3) Multivariate logistic regression revealed that age, CD4⁺ T lymphocyte count, and ANA positivity were independent factors for chronicity in pediatric ITP (P < 0.05). Children with ITP who were older at diagnosis and had a positive ANA were more likely to progress to chronic ITP; the higher CD4⁺ T lymphocyte counts may be protective. These factors may assist in early risk stratification and help identify patients requiring closer monitoring, thereby providing a reference for prognosis evaluation. However, their role in guiding individualized treatment strategies requires further validation in prospective studies.
SN - 2045-2322
ER -