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Peer-reviewedCC BYBrain and behavior

Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder.

  • Lu Yang1
  • Liemin Ruan1
  • Zhongze Lou1
  • Zhenglai Liu1
  • Yiqin Huang1
  • Li Zhang1
  • Yunxin Ji1
  1. 1Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
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Abstract

Objective

This study aimed to investigate cognitive function changes in adolescents with major depressive disorder (MDD) and examine their associations with depression severity, event-related potentials (ERP), T lymphocyte subsets, and inflammatory cytokines to identify exploratory clinical and biological correlates for cognitive impairment in this population.Methods

We enrolled 89 adolescent patients with MDD and 30 healthy controls, matched for age and gender. Cognitive function was assessed using the Montreal Cognitive Assessment Scale (MoCA), depression severity with the Hamilton Depression Scale (HAMD17), and anxiety with the Hamilton Anxiety Scale. ERP were recorded, and blood samples were analyzed for T lymphocyte subsets and inflammatory cytokines.Results

Adolescents with MDD exhibited significantly lower MoCA scores, indicating cognitive impairment, particularly in attention, delayed recall, and executive function. ERP component analysis showed prolonged latencies and decreased amplitudes in the MDD group. Increased serum concentrations of interleukin-1 beta and interleukin-6, and elevated percentages of CD3+CD4+ and CD3+CD8+ cells were observed in the depressive group, with positive correlations between CD3+ cells and MoCA scores and between CD3+CD8+ cells and HAMD17 scores.Conclusion

Adolescents with MDD showed lower cognitive performance, which was associated with depression severity and immune-inflammatory indicators.

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Cite

BibTeXRIS
BibTeX
@article{yang2026association,
  title = {{Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder.}},
  author = {Lu Yang and Liemin Ruan and Zhongze Lou and Zhenglai Liu and Yiqin Huang and Li Zhang and Yunxin Ji},
  journal = {Brain and behavior},
  year = {2026},
  month = oct,
  doi = {10.1002/brb3.71802},
  url = {https://europepmc.org/article/MED/42894373},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder.
AU  - Lu Yang
AU  - Liemin Ruan
AU  - Zhongze Lou
AU  - Zhenglai Liu
AU  - Yiqin Huang
AU  - Li Zhang
AU  - Yunxin Ji
PY  - 2026
DA  - 2026/10/01
JO  - Brain and behavior
DO  - 10.1002/brb3.71802
UR  - https://europepmc.org/article/MED/42894373
AB  - Objective  This study aimed to investigate cognitive function changes in adolescents with major depressive disorder (MDD) and examine their associations with depression severity, event-related potentials (ERP), T lymphocyte subsets, and inflammatory cytokines to identify exploratory clinical and biological correlates for cognitive impairment in this population.Methods  We enrolled 89 adolescent patients with MDD and 30 healthy controls, matched for age and gender. Cognitive function was assessed using the Montreal Cognitive Assessment Scale (MoCA), depression severity with the Hamilton Depression Scale (HAMD17), and anxiety with the Hamilton Anxiety Scale. ERP were recorded, and blood samples were analyzed for T lymphocyte subsets and inflammatory cytokines.Results  Adolescents with MDD exhibited significantly lower MoCA scores, indicating cognitive impairment, particularly in attention, delayed recall, and executive function. ERP component analysis showed prolonged latencies and decreased amplitudes in the MDD group. Increased serum concentrations of interleukin-1 beta and interleukin-6, and elevated percentages of CD3+CD4+ and CD3+CD8+ cells were observed in the depressive group, with positive correlations between CD3+ cells and MoCA scores and between CD3+CD8+ cells and HAMD17 scores.Conclusion  Adolescents with MDD showed lower cognitive performance, which was associated with depression severity and immune-inflammatory indicators.
SN  - 2162-3279
ER  -